{"title":"Insulin resistance versus dysregulation—a distinction without a difference","authors":"E. M. Kellon","doi":"10.1111/eve.14082","DOIUrl":null,"url":null,"abstract":"<p>For the last 10 years, the term ‘insulin dysregulation’ has replaced ‘insulin resistance’ when referring to horses with hyperinsulinaemia. The rationale was that this was an all-inclusive term that covered all possible causes of hyperinsulinaemia. The implication is that hyperinsulinaemia has been shown to occur outside of insulin resistance; with insulin resistance being defined as failure of the insulin-sensitive cells to respond normally to insulin, as best documented by the euglycaemic hyperinsulinaemic clamp. This article will show the evidence for that is weak to nonexistent in the horse and the term ‘insulin dysregulation’ is a misnomer that should be abandoned.</p>","PeriodicalId":11786,"journal":{"name":"Equine Veterinary Education","volume":"37 4","pages":"210-215"},"PeriodicalIF":0.8000,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eve.14082","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Equine Veterinary Education","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/eve.14082","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
For the last 10 years, the term ‘insulin dysregulation’ has replaced ‘insulin resistance’ when referring to horses with hyperinsulinaemia. The rationale was that this was an all-inclusive term that covered all possible causes of hyperinsulinaemia. The implication is that hyperinsulinaemia has been shown to occur outside of insulin resistance; with insulin resistance being defined as failure of the insulin-sensitive cells to respond normally to insulin, as best documented by the euglycaemic hyperinsulinaemic clamp. This article will show the evidence for that is weak to nonexistent in the horse and the term ‘insulin dysregulation’ is a misnomer that should be abandoned.
期刊介绍：
Equine Veterinary Education (EVE) is the official journal of post-graduate education of both the British Equine Veterinary Association (BEVA) and the American Association of Equine Practitioners (AAEP).
Equine Veterinary Education is a monthly, peer-reviewed, subscription-based journal, integrating clinical research papers, review articles and case reports from international sources, covering all aspects of medicine and surgery relating to equids. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of equine medicine and surgery. The educational value of a submitted article is one of the most important criteria that are assessed when deciding whether to accept it for publication. Articles do not necessarily need to contain original or novel information but we welcome submission of this material. The educational value of an article may relate to articles published with it (e.g. a Case Report may not have direct educational value but an associated Clinical Commentary or Review Article published alongside it will enhance the educational value).
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