Nanocellulose/Graphene Oxide Composite Beads as a Novel Hemoperfusion Adsorbent for Efficient Removal of Bilirubin Plasma

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomacromolecules Pub Date : 2025-04-14 Epub Date: 2025-03-04 DOI:10.1021/acs.biomac.4c01838

Xuanru Wei , Hengfeng Zhu , Dichan Hong , Xiangxian Li , Zhuqun Shi , Quanling Yang

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Abstract

Conventional hemoperfusion adsorbents suffer from inefficiency and poor biocompatibility. Cellulose, a natural polysaccharide with biocompatible, biodegradable, and nontoxic properties, was combined with graphene oxide (GO) to fabricate composite beads (TGO) for blood purification. GO synthesized via a modified Hummers method was complexed with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibrils (TOCNs). Increasing GO content (2–20 wt %) enhanced TGO’s specific surface area (256.4–289.0 m² g^–1) while retaining an ∼10 nm pore size. TGO demonstrated exceptional adsorption capacities: bilirubin (418.4 mg g^–1), creatinine (23.5 mg g^–1), uric acid (146.6 mg g^–1), and Cu²⁺ (171.9 mg g^–1). The beads exhibited excellent hemocompatibility (hemolysis rate <5%) and prolonged recalcification time (585 ± 5.2 s). Notably, TGO restored blood bilirubin levels to normal within 30 min, highlighting its potential for blood purification.

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纳米纤维素/氧化石墨烯复合微珠作为高效去除胆红素血浆的新型血液灌流吸附剂。

传统的血液灌流吸附剂效率低，生物相容性差。纤维素是一种具有生物相容性、可生物降解和无毒特性的天然多糖，将其与氧化石墨烯（GO）结合，制成用于血液净化的复合微珠（TGO）。采用改进的Hummers方法合成氧化石墨烯，并与2,2,6,6-四甲基哌啶-1-氧基（TEMPO）氧化纤维素纳米原纤维（TOCNs）络合。增加氧化石墨烯含量（2-20 wt %）增强了氧化石墨烯的比表面积（256.4-289.0 m2 g-1），同时保持了约10 nm的孔径。TGO具有优异的吸附能力：胆红素（418.4 mg g-1）、肌酐（23.5 mg g-1）、尿酸（146.6 mg g-1）和Cu2+ (171.9 mg g-1)。微球具有良好的血液相容性（溶血率）

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文献相关原料

公司名称

产品信息

麦克林

bilirubin

阿拉丁

uric acid

阿拉丁

creatinine

阿拉丁

NaClO

来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.