Phytochemical and pharmacological characterisation of extracts from Scorzonera undulata Vahl. roots.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-03-05 DOI:10.1080/14786419.2025.2472273

Imen Bédoui, Hmed Ben-Nasr, Kamilia Ksouda, Ahlem Chira, Riadh Ben Mansour, Bochra Gargouri, Mohamed Chamkha, Amina Maalej, Slim Charfi, Hanen Affes, Serria Hammami, Khaled Zghal

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Abstract

Scorzonera undulata Vahl. roots are used for their nutraceutical and medicinal properties. In this work, GC-MS revealed that polysaccharides (P) and the methanolic extract (MB) of S. undulata roots contained 8 and 7 different components, respectively. They also potently inhibited the Free DPPH radical (IC50% equals 103 ± 0.01 and 105 ± 0.01 µg/ml, respectively) and the viability of Hela cancer cell line (IC50 of 2.074 ± 0.05 mg/ml and 2.208 ± 0.05 mg/ml respectively). Furthermore, polysaccharides showed a relevant anti-inflammatory effect, as assayed by on carrageenan-induced paw edoema model. S. undulata contains several active molecules such as derivatives of gluconic acid, hexapyranosids, arabinofuranoside, and xylofuranose that might be useful in preventing and treating cancer and inflammation. It merits further investigations to pinpoint their mechanisms of action and their properties as a functional food.

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山葵提取物的植物化学和药理特性研究。的根源。

山葵。根因其营养和药用特性而被使用。通过气相色谱-质谱分析发现，山竹根多糖(P)和甲醇提取物（MB）分别含有8种和7种不同的成分。它们还能有效抑制游离DPPH自由基（IC50分别为103±0.01和105±0.01µg/ml）和Hela癌细胞的活性（IC50分别为2.074±0.05 mg/ml和2.208±0.05 mg/ml）。此外，在卡拉胶诱导的足跖水肿模型中，多糖显示出相应的抗炎作用。波曲草含有几种活性分子，如葡萄糖酸、六吡喃苷、阿拉伯糖呋喃苷和木糖呋喃糖的衍生物，可能对预防和治疗癌症和炎症有用。它值得进一步的研究，以确定其作用机制和它们的特性作为一种功能性食品。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.