Recent Advances in the Synthesis of Indolo[2,1-a]isoquinoline Derivatives

Abstract

Abstract: Indole[2,1-a]isoquinoline structures are widely present in many drug molecules and natural product molecules. Its derivatives have a wide range of physiological and pharmacological activities such as antibacterial, antiviral, anti-tumor, anti-cytostatic, anti-venom, and as an inhibitor of tubulin polymerization properties. They are also important intermediates in organic synthesis and structural units in drug synthesis. Therefore, indole[2,1-a]isoquinoline compounds have great application value in the pharmaceutical field. The study of its synthesis methods has also become an important research field of organic synthesis. At present, chemists have developed many efficient methods for synthesizing indole[2,1-a]isoquinoline derivatives. This paper reviews the research progress in the synthesis methods and application of indole[2,1-a]isoquinoline compounds in recent years, and representative examples and reaction mechanisms are discussed. Content 1. Introduction 2. Synthesis of indolo[2,1-a]isoquinoline derivatives 2.1 Metal catalytic system 2.2 Metal catalysis free system 2.3 Photocatalytic system 2.4 Electrocatalytic system 2.5 Catalyst free system 2.6 Other preparation methods for indolo[2,1-a]isoquinoline derivatives 3. Summary and Outlook