Microneedles with an anisotropic porous microstructure facilitate the transdermal delivery of small molecules, lipid nanoparticles, and T cells

IF 17.3 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Matter Pub Date : 2025-03-06 DOI:10.1016/j.matt.2025.102038

Tianli Hu, Ka Sin Lui, Eira Beryle Ko, Yayi Zhao, Qizheng Zhang, Huaxin Yang, Mengjia Zheng, Hao Chang, Baolin Guo, Allen Ka Loon Cheung, Chenjie Xu

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Abstract

Porous microneedles (MNs) offer optimal performance for drug delivery and biofluid sampling. However, current porous MNs suffer from randomly interconnected pores, and existing fabrication methods lack control over pore diameter and orientation. This study employs a freeze-casting technique to precisely control these parameters in MNs, inspired by the anisotropic porous structure of wood xylem. This specialized microstructure enables rapid liquid absorption from the tips to the base within seconds, making it an effective tear-sampling tool to monitor tear biomarkers—a capability confirmed in rat models of dry-eye disease and diabetes. Additionally, these anisotropic porous MNs facilitate the active loading of various drugs, including γδ T cells, from the base to the tips without the need for specialized equipment. The delivery of γδ T cells via MNs has shown efficacy against tumors in both xenograft melanoma and pleural mesothelioma mouse models, presenting a novel approach to adoptive cell therapy.

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来源期刊

Matter MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

26.30

自引率

2.60%

发文量

367

期刊介绍： Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content. Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.