Sr-doped MnO2 with enhanced dual-enzyme mimetic activity for colorimetric detection of glutathione and 2,4-dichlorophenol

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchemical Journal Pub Date : 2025-03-01 DOI:10.1016/j.microc.2025.113166

Wei Shi , Xueyi Wang , Zhouping Yang , Jun Yang , Xiaoying Fu , Xianxiang Wang

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Abstract

The development of simple and rapid colorimetric methods for monitoring food nutrition and safety is essential for sustaining life and promoting health. Nanozymes, which exhibit high stability and multi-enzyme activity, hold significant promise for widespread applications in colorimetric analysis. In this work, we successfully synthesized strontium-doped MnO₂ nanoflowers (Sr-MnO₂ NFs) that exhibit both oxidase-like and laccase-like activities. The oxidase activity and laccase activity of the Sr-MnO₂ NFs were 2.12 and 3 times greater than those of MnO₂ nanorods (MnO₂ NRs), respectively. Oxygen vacancies (Ov) and O₂⁻ play a key role in oxidase-like and laccase-like enzymes. Leveraging the excellent catalytic properties of these activities, we developed a simple, fast and highly sensitive colorimetric detection method for glutathione (GSH) and 2,4-dichlorophenol (2,4-DP), achieving low detection limits of 0.46 μM and 0.992 μM, respectively. Furthermore, the proposed method has been successfully applied to the determination of GSH and 2,4-DP in food samples.

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掺锶二氧化锰具有增强的双酶模拟活性，可用于谷胱甘肽和 2,4-二氯苯酚的比色检测

开发简单快速的比色法监测食品营养和安全对于维持生命和促进健康至关重要。纳米酶具有高稳定性和多酶活性，在比色分析中具有广泛的应用前景。在这项工作中，我们成功地合成了具有氧化酶和漆酶活性的锶掺杂MnO2纳米花（Sr-MnO2 NFs）。Sr-MnO2纳米棒的氧化酶活性和漆酶活性分别是MnO2纳米棒的2.12倍和3倍。氧空位（Ov）和O2−在类氧化酶和类漆酶中起关键作用。利用这些活性的优异催化性能，我们建立了一种简单、快速、高灵敏度的谷胱甘肽（GSH）和2,4-二氯苯酚（2,4- dp）的比色检测方法，检测限分别为0.46 μM和0.992 μM。该方法已成功地应用于食品样品中谷胱甘肽和2,4- dp的测定。

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文献相关原料

公司名称

产品信息

麦克林

glutathione

麦克林

sodium acetate

麦克林

acetic acid

麦克林

4-aminoantipyrine

麦克林

2,4-dichlorophenol

麦克林

3,3′,5,5′-tetramethylbenzidine

麦克林

Manganese triacetate dihydrate

麦克林

potassium hydroxide

麦克林

potassium permanganate

麦克林

strontium chloride

麦克林

glutathione

麦克林

sodium acetate

麦克林

acetic acid

麦克林

4-aminoantipyrine

麦克林

2,4-dichlorophenol

麦克林

3,3′,5,5′-tetramethylbenzidine

麦克林

Manganese triacetate dihydrate

麦克林

potassium hydroxide

麦克林

potassium permanganate

麦克林

strontium chloride

阿拉丁

Dimethyl sulfoxide

来源期刊

Microchemical Journal 化学-分析化学

CiteScore

8.70

自引率

8.30%

发文量

1131

审稿时长

1.9 months

期刊介绍： The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.