{"title":"Multifaceted regulation of asymmetric cell division by the actin cytoskeleton","authors":"Peishan Yi , Guangshuo Ou , Wei Li","doi":"10.1016/j.ceb.2025.102491","DOIUrl":null,"url":null,"abstract":"<div><div>Asymmetric cell division (ACD) is essential for generating cell diversity in multicellular eukaryotes, yet the underlying mechanisms remain largely unresolved. Well-established models of ACD, such as microtubule-based spindle displacement in <em>Caenorhabditis elegans</em> embryos and preprophase band assembly in plants provide valuable insights but fail to fully explain asymmetry establishment in others. In this article, we discuss how actin-dependent mechanisms govern ACD in model systems, highlighting emerging commonalities and differences. Given its broad impact, the actin cytoskeleton may play a more significant role in ACD than currently recognized, serving as a fundamental component during organismal development across kingdoms.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102491"},"PeriodicalIF":6.0000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0955067425000298","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Asymmetric cell division (ACD) is essential for generating cell diversity in multicellular eukaryotes, yet the underlying mechanisms remain largely unresolved. Well-established models of ACD, such as microtubule-based spindle displacement in Caenorhabditis elegans embryos and preprophase band assembly in plants provide valuable insights but fail to fully explain asymmetry establishment in others. In this article, we discuss how actin-dependent mechanisms govern ACD in model systems, highlighting emerging commonalities and differences. Given its broad impact, the actin cytoskeleton may play a more significant role in ACD than currently recognized, serving as a fundamental component during organismal development across kingdoms.
期刊介绍：
Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings.
COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
