Cobalt(II) complexes of tri-dentate S,N,S-thiophenyl Schiff base ligand for prospective biological studies and ct-DNA interaction. Catalytic benzyl alcohol oxidative performance
Zakaria S. Bakhuraisa , Ahmed Khalil , Mustafa J. Abdelmageed Abualreish , Ahmed Desoky M. Mohamad , Mamdouh A. Mohamed , Mohamed Shaker S. Adam
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引用次数: 0
Abstract
The condensing reaction of thiophene-2-carbaldehyde with 2-aminobenzenethiol yielded S,N,S-thiophenyl Schiff base ligand (HLNS). In various molar ratios, the coordination behavior of HLNS towards cobalt(II) ions was studied within 1 and 2: 1 equivalents, resulting in the formation of two diverse structural complexes, [CoLNSCl(H2O)2] and [Co(LNS)2], respectively. Their structural elucidation was achieved using various spectroscopic methods, which involved thermogravimetric assessments, elemental analysis, magnetic characteristics, and conductivity measurements.
The inhibitory influence of HLNS (as an unbonded ligand) and its cobalt(II)-chelating agents on the restrained proliferation of three particular microbes of bacterial and fungal strains, and three recognized cell lines of human cancer were assessed assigning the structural effect on the reactivity of [CoLNSCl(H2O)2] and [Co(LNS)2] versus their free ligand (HLNS). The study sought to ascertain the predominant role of Co(II) ions in the two chelates on the binding strength of HLNS, [CoLNSCl(H2O)2], and [Co(LNS)2] towards calf thymus DNA (ct-DNA), which was evaluated by examining the changes in their viscometric and spectrophotometric characteristics. The evaluation of binding constants (Kb), Gibbs free energy , and chromism modes was utilized to analyze the interaction modes of the current compounds with ct-DNA compared to that action of HLNS.
[CoLNSCl(H2O)2] and [Co(LNS)2] represented high catalytic oxidative performance for benzyl alcohol with hydrogen peroxide homogeneously. At 80 °C, the yielding percentage of the selective-product (benzaldehyde) was 85 % after 4 h and 82 % after 5 h with [CoLNSCl(H2O)2] and [Co(LNS)2], respectively. The variation in the optimal atmosphere for both catalysts referred to their molecular structure differences.
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