CORM-Mediated Pd-Catalyzed Coupling Reactions: Ketone Synthesis and CO-Releasing Mechanisms

IF 3.9 3区化学 Q2 CHEMISTRY, PHYSICAL ChemCatChem Pub Date : 2024-12-23 DOI:10.1002/cctc.202401253

Meng Guo, Hongyu Yang, Jiawei Wang, Yajun Jian, Weiqiang Zhang, Ziwei Gao

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Abstract

Palladium-catalyzed carbonylative C─C coupling reactions provide an efficient route to synthesize natural products and pharmaceuticals through three-component condensation processes. However, the use of gaseous carbon monoxide (CO) – a colorless, odorless, and toxic gas – has hindered its broad adoption as a C1 source. Addressing this, the development of versatile CO-releasing molecules (CORMs) and user-friendly, nongaseous palladium-catalyzed carbonylation techniques have emerged as a crucial research area. This review outlines recent advancements in the application of CORMs to palladium-catalyzed carbonylative C─C coupling reactions, with a focus on CO generation mechanisms and carbonyl utilization efficiency. CORMs are classified into three categories: single carbon monoxide releasing molecules (s-CORMs), multiple carbon monoxide releasing molecules (m-CORMs), and binary metal carbonyl compounds (BMCCs). By offering a comprehensive overview of the current research landscape and providing practical guidelines for CORM selection, this review aims to assist researchers in developing effective carbonylative strategies.

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corm介导的pd催化偶联反应：酮合成和共释放机制

钯催化羰基化C─C偶联反应为三组分缩合合成天然产物和药物提供了一条有效途径。然而，气态一氧化碳（CO）——一种无色、无味和有毒的气体——的使用阻碍了它作为C1源的广泛采用。为了解决这一问题，开发多功能co释放分子（corm）和用户友好的非质钯催化羰基化技术已成为一个关键的研究领域。本文综述了CORMs在钯催化羰基化C─C偶联反应中的应用进展，重点介绍了CO的生成机理和羰基利用效率。一氧化碳化合物可分为三大类：单一氧化碳释放分子（s-CORMs）、多一氧化碳释放分子（m-CORMs）和二元金属羰基化合物（bmcs）。通过对当前研究前景的全面概述，并为CORM的选择提供实用指南，本综述旨在帮助研究人员制定有效的羰基化策略。

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来源期刊

ChemCatChem 化学-物理化学

CiteScore

8.10

自引率

4.40%

发文量

511

审稿时长

1.3 months

期刊介绍： With an impact factor of 4.495 (2018), ChemCatChem is one of the premier journals in the field of catalysis. The journal provides primary research papers and critical secondary information on heterogeneous, homogeneous and bio- and nanocatalysis. The journal is well placed to strengthen cross-communication within between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and is supported by the German Catalysis Society.