Small nucleolar RNAs: the hidden precursors of cancer ribosomes.

IF 4.7 2区生物学 Q1 BIOLOGY Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2025-03-06 DOI:10.1098/rstb.2023.0376

Laurence Faucher-Giguère, Baudouin S de Préval, Andrea Rivera, Michelle S Scott, Sherif Abou Elela

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Abstract

Ribosomes are heterogeneous in terms of their constituent proteins, structural RNAs and ribosomal RNA (rRNA) modifications, resulting in diverse potential translatomes. rRNA modifications, guided by small nucleolar RNAs (snoRNAs), enable fine-tuning of ribosome function and translation profiles. Recent studies have begun linking dysregulation of snoRNAs, via rRNA modifications, to tumourigenesis. Deciphering the specific contributions of individual rRNA modifications to cancer hallmarks and identifying snoRNAs with oncogenic potential could lead to novel therapeutic strategies. These strategies might target snoRNAs or exploit the dependence of cancer cells on specific rRNA modification sites, potentially disrupting aberrant ribosomal translation programs and hindering tumour growth. This review discusses current evidence and challenges in linking changes in snoRNA expression to rRNA modification and cancer biology.This article is part of the discussion meeting issue 'Ribosome diversity and its impact on protein synthesis, development and disease'.

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核极小 RNA：癌症核糖体的隐藏前体。

核糖体在其组成蛋白、结构RNA和核糖体RNA （rRNA）修饰方面是异质的，导致潜在的翻译体多种多样。在小核仁rna （small nucleolar rna, snoRNAs）的引导下，rRNA修饰能够对核糖体功能和翻译谱进行微调。最近的研究已经开始通过rRNA修饰将snorna的失调与肿瘤发生联系起来。破译单个rRNA修饰对癌症标志的特定贡献，识别具有致癌潜力的snorna，可能会带来新的治疗策略。这些策略可能针对snoRNAs或利用癌细胞对特定rRNA修饰位点的依赖性，潜在地破坏异常核糖体翻译程序并阻碍肿瘤生长。这篇综述讨论了将snoRNA表达变化与rRNA修饰和癌症生物学联系起来的现有证据和挑战。本文是“核糖体多样性及其对蛋白质合成、发育和疾病的影响”讨论会的一部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Philosophical Transactions of the Royal Society B: Biological Sciences 生物-生物学

CiteScore

11.80

自引率

1.60%

发文量

365

审稿时长

3 months

期刊介绍： The journal publishes topics across the life sciences. As long as the core subject lies within the biological sciences, some issues may also include content crossing into other areas such as the physical sciences, social sciences, biophysics, policy, economics etc. Issues generally sit within four broad areas (although many issues sit across these areas): Organismal, environmental and evolutionary biology Neuroscience and cognition Cellular, molecular and developmental biology Health and disease.

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