Mechanisms of Antioxidant Protection of Low-Density Lipoprotein Particles Against Free Radical Oxidation

IF 2.2 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow) Pub Date : 2025-03-07 DOI:10.1134/S0006297924603381

Vadim Z. Lankin, Konstantin B. Shumaev, Valeria A. Medvedeva, Alla K. Tikhaze, Galina G. Konovalova

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Abstract

It was found out that when the patients with atherosclerosis are orally administered ubiquinone Q₁₀ (CoQ₁₀), oxidation (lipid hydroperoxide content) of the low-density lipoprotein (LDL) particles sharply decreases, which confirms important role of this natural antioxidant in protecting LDL particles from free radical oxidation in vivo. Influence of the lipophilic natural antioxidants ubiquinol Q₁₀ (CoQ₁₀H₂) and α-tocopherol (α-TOH) on the kinetic parameters of Cu²⁺-induced free radical oxidation of LDL particles was investigated. In this model system, possible synergism of the antioxidant action of CoQ₁₀H₂ and α-TOH has been shown. Putative mechanisms of bioregeneration of lipophilic antioxidants in LDL particles, including regeneration of α-TOH from the tocopheroxyl radical (α-TO^•) with participation of CoQ₁₀H₂ and/or ascorbate, are discussed.

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低密度脂蛋白颗粒抗自由基氧化的抗氧化保护机制

研究发现，动脉粥样硬化患者口服泛醌 Q10（CoQ10）后，低密度脂蛋白（LDL）颗粒的氧化（脂质氢过氧化物含量）会急剧下降，这证实了这种天然抗氧化剂在体内保护低密度脂蛋白颗粒免受自由基氧化的重要作用。研究了亲脂性天然抗氧化剂泛醌醇 Q10（CoQ10H2）和α-生育酚（α-TOH）对 Cu2+ 诱导的 LDL 颗粒自由基氧化动力学参数的影响。在该模型系统中，CoQ10H2 和 α-TOH 的抗氧化作用可能具有协同作用。研究还讨论了低密度脂蛋白颗粒中亲脂性抗氧化剂的生物再生机制，包括在 CoQ10H2 和/或抗坏血酸的参与下，从生育酚自由基（α-TO-）中再生出 α-TOH。

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来源期刊

Biochemistry (Moscow) 生物-生化与分子生物学

CiteScore

4.70

自引率

3.60%

发文量

139

审稿时长

2 months

期刊介绍： Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).