Mechanisms of Antioxidant Protection of Low-Density Lipoprotein Particles Against Free Radical Oxidation

IF 2.3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow) Pub Date : 2025-03-07 DOI:10.1134/S0006297924603381

Vadim Z. Lankin, Konstantin B. Shumaev, Valeria A. Medvedeva, Alla K. Tikhaze, Galina G. Konovalova

{"title":"Mechanisms of Antioxidant Protection of Low-Density Lipoprotein Particles Against Free Radical Oxidation","authors":"Vadim Z. Lankin, Konstantin B. Shumaev, Valeria A. Medvedeva, Alla K. Tikhaze, Galina G. Konovalova","doi":"10.1134/S0006297924603381","DOIUrl":null,"url":null,"abstract":"It was found out that when the patients with atherosclerosis are orally administered ubiquinone Q10 (CoQ10), oxidation (lipid hydroperoxide content) of the low-density lipoprotein (LDL) particles sharply decreases, which confirms important role of this natural antioxidant in protecting LDL particles from free radical oxidation in vivo. Influence of the lipophilic natural antioxidants ubiquinol Q10 (CoQ10H2) and α-tocopherol (α-TOH) on the kinetic parameters of Cu2+-induced free radical oxidation of LDL particles was investigated. In this model system, possible synergism of the antioxidant action of CoQ10H2 and α-TOH has been shown. Putative mechanisms of bioregeneration of lipophilic antioxidants in LDL particles, including regeneration of α-TOH from the tocopheroxyl radical (α-TO•) with participation of CoQ10H2 and/or ascorbate, are discussed.","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 1","pages":"107 - 119"},"PeriodicalIF":2.3000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry (Moscow)","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1134/S0006297924603381","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

It was found out that when the patients with atherosclerosis are orally administered ubiquinone Q₁₀ (CoQ₁₀), oxidation (lipid hydroperoxide content) of the low-density lipoprotein (LDL) particles sharply decreases, which confirms important role of this natural antioxidant in protecting LDL particles from free radical oxidation in vivo. Influence of the lipophilic natural antioxidants ubiquinol Q₁₀ (CoQ₁₀H₂) and α-tocopherol (α-TOH) on the kinetic parameters of Cu²⁺-induced free radical oxidation of LDL particles was investigated. In this model system, possible synergism of the antioxidant action of CoQ₁₀H₂ and α-TOH has been shown. Putative mechanisms of bioregeneration of lipophilic antioxidants in LDL particles, including regeneration of α-TOH from the tocopheroxyl radical (α-TO^•) with participation of CoQ₁₀H₂ and/or ascorbate, are discussed.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Biochemistry (Moscow) 生物-生化与分子生物学

CiteScore

4.70

自引率

3.60%

发文量

139

审稿时长

2 months

期刊介绍： Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).