Anti-Leukotriene Receptor Blockers Improve Tendon-Bone Interface Healing in a Rat Model of Acute Rotator Cuff Tear.

IF 1.2 4区医学 Q3 ORTHOPEDICS Orthopedics Pub Date : 2025-03-01 Epub Date: 2025-03-04 DOI:10.3928/01477447-20250218-01

Jong Pil Yoon, Sung-Jin Park, Dong-Hyun Kim, Yoon Seong Choi, Hyun Joo Lee, Jun-Young Kim, Seok Won Chung

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Abstract

Background: Excessive expression of proinflammatory cytokines after rotator cuff (RC) surgery impairs the quality of tendon-bone interface (TBI) healing. There is evidence that the asthma drug montelukast (MS) inhibits the expression of proinflammatory cytokines. This study was conducted to verify the effect of MS administration on TBI healing after RC repair.

Materials and methods: Thirteen rats in the MS group were intraperitoneally administered 10 mg/kg of the drug daily for 2 weeks after RC surgery, and 13 rats in the control group were administered only 0.9% saline. The healing effect of the TBI was assessed through histologic and biomechanical analysis 4 weeks after tendon repair.

Results: In the MS group, the expression of interleukin-1 beta (IL-1β; P<.01) and interleukin 6 (IL-6; P<.01) was significantly reduced compared with the control group. In the evaluation of supraspinatus fatty infiltration, the MS group showed significant inhibition of fatty infiltration compared with the control group (P<.001). Histologic analysis showed that the MS group had significant improvements in collagen density (P=.035) and alignment (P=.011). Biomechanical analysis after systemic administration of MS showed an increase in the cross-sectional area (P<.001) and elongation (P<.01) of the TBI.

Conclusion: The use of MS improved tendon elasticity through suppressing fatty infiltration and improving TBI collagen density and arrangement. The mechanism is down-regulation of IL-1β and IL-6. These results strongly support the use of MS as an anti-inflammatory agent that does not impair tendon healing. [Orthopedics. 2025;48(2):e105-e112.].

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抗白三烯受体阻滞剂可改善急性肩袖撕裂大鼠模型中肌腱-骨界面的愈合。

背景：肩袖（RC）手术后过度表达促炎因子会损害肌腱-骨界面（TBI）愈合质量。有证据表明，哮喘药物孟鲁司特（MS）抑制促炎细胞因子的表达。本研究旨在验证MS对RC修复后TBI愈合的影响。材料与方法：RC术后，MS组13只大鼠每日腹腔注射10 mg/kg药物，持续2周，对照组13只大鼠只注射0.9%生理盐水。肌腱修复后4周，通过组织学和生物力学分析评估TBI的愈合效果。结果：MS组白细胞介素-1β (IL-1β；PPPP= 0.035)和对齐（P= 0.011）。全身给药后的生物力学分析显示，横断面积增加（ppp）。结论：使用MS可通过抑制脂肪浸润和改善TBI胶原密度和排列来改善肌腱弹性。其机制是下调IL-1β和IL-6。这些结果有力地支持MS作为一种不损害肌腱愈合的抗炎剂的使用。[矫形手术。202 x; 4 x (x): xx-xx。]。

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来源期刊

Orthopedics 医学-整形外科

CiteScore

2.20

自引率

0.00%

发文量

160

审稿时长

3 months

期刊介绍： For over 40 years, Orthopedics, a bimonthly peer-reviewed journal, has been the preferred choice of orthopedic surgeons for clinically relevant information on all aspects of adult and pediatric orthopedic surgery and treatment. Edited by Robert D''Ambrosia, MD, Chairman of the Department of Orthopedics at the University of Colorado, Denver, and former President of the American Academy of Orthopaedic Surgeons, as well as an Editorial Board of over 100 international orthopedists, Orthopedics is the source to turn to for guidance in your practice. The journal offers access to current articles, as well as several years of archived content. Highlights also include Blue Ribbon articles published full text in print and online, as well as Tips & Techniques posted with every issue.