A subtype of T cells impedes tissue repair in aged spinal cord after injury.

IF 15 1区 医学 Q1 NEUROSCIENCES Neuron Pub Date : 2025-03-05 DOI:10.1016/j.neuron.2025.02.011
Chengle Zhang, Kai Liu
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引用次数: 0

Abstract

In this issue of Neuron, Kong et al.1 identify targetable natural killer-like T cells that seed the intact aged human and murine spinal cords and increase further after injury. These cells impede myeloid-cell-dependent wound healing in the aged injured cord through expressing natural killer cell granule protein 7 (NKG7).

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一种T细胞亚型阻碍损伤后老年脊髓的组织修复。
在这一期的《神经元》杂志上,Kong等人1发现了可靶向的自然杀伤样T细胞,这些T细胞在完整的老年人类和小鼠脊髓中植入,并在损伤后进一步增加。这些细胞通过表达自然杀伤细胞颗粒蛋白7 (NKG7)阻碍年老损伤脊髓的髓细胞依赖性伤口愈合。
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来源期刊
Neuron
Neuron 医学-神经科学
CiteScore
24.50
自引率
3.10%
发文量
382
审稿时长
1 months
期刊介绍: Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.
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