{"title":"New mechanisms highlight the complex relationship of Apolipoprotein E and tau pathogenesis.","authors":"Paramita Chakrabarty, Conner Angelle","doi":"10.1016/j.neuron.2025.01.025","DOIUrl":null,"url":null,"abstract":"<p><p>A rare variant of Apolipoprotein E3 with neuroprotective properties has been identified in autosomal-dominant Alzheimer's disease. In this issue of Neuron, Chen et al.<sup>1</sup> show that direct interaction between this variant and tau blocks tau pathogenesis in rodent models.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"113 5","pages":"646-648"},"PeriodicalIF":14.7000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuron","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuron.2025.01.025","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
A rare variant of Apolipoprotein E3 with neuroprotective properties has been identified in autosomal-dominant Alzheimer's disease. In this issue of Neuron, Chen et al.1 show that direct interaction between this variant and tau blocks tau pathogenesis in rodent models.
期刊介绍：
Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.
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