Maternal and Neonatal Hemorrhage From Vitamin K Deficiency in the Setting of Crohn Disease in Pregnancy.

IF 5.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY Obstetrics and gynecology Pub Date : 2025-03-06 DOI:10.1097/AOG.0000000000005870

Sydney Lammers, Nicholas A Iovino, Antoinette Pusateri, Andrea Snyder, Madalina Butnariu, Heather A Frey, Jacob Skeans

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Abstract

Background: Patients with inflammatory bowel disease, particularly Crohn disease (CD), are at increased risk of fat malabsorption and fat-soluble vitamin deficiencies. Vitamin K is a fat-soluble vitamin that plays a critical role in blood coagulation. Vitamin K deficiency during pregnancy can lead to severe maternal and neonatal hemorrhagic complications.

Case: We report the case of a patient with severe CD requiring extensive bowel resection who acquired vitamin K deficiency during pregnancy. During pregnancy, the patient experienced epistaxis, easy bruising, and intermittent gum bleeding. The patient and neonate experienced significant hemorrhagic morbidity secondary to vitamin K deficiency after cesarean delivery at 35 3/7 weeks of gestation for nonreassuring fetal well-being.

Conclusion: Vitamin K deficiency is a rare complication of CD that can result in life-threatening maternal and neonatal outcomes. Clinicians caring for patients with severe CD with prior bowel resection and risk factors for fat malabsorption should consider screening for vitamin K deficiency during pregnancy.

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来源期刊

Obstetrics and gynecology 医学-妇产科学

CiteScore

11.10

自引率

4.20%

发文量

867

审稿时长

1 months

期刊介绍： "Obstetrics & Gynecology," affectionately known as "The Green Journal," is the official publication of the American College of Obstetricians and Gynecologists (ACOG). Since its inception in 1953, the journal has been dedicated to advancing the clinical practice of obstetrics and gynecology, as well as related fields. The journal's mission is to promote excellence in these areas by publishing a diverse range of articles that cover translational and clinical topics. "Obstetrics & Gynecology" provides a platform for the dissemination of evidence-based research, clinical guidelines, and expert opinions that are essential for the continuous improvement of women's health care. The journal's content is designed to inform and educate obstetricians, gynecologists, and other healthcare professionals, ensuring that they stay abreast of the latest developments and best practices in their field.

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