Visual Statistical Learning Alters Low-Dimensional Cortical Architecture.

Abstract

Our brains are in a constant state of generating predictions, implicitly extracting environmental regularities to support later cognition and behavior, a process known as statistical learning (SL). While prior work investigating the neural basis of SL has focused on the activity of single brain regions in isolation, much less is known about how distributed brain areas coordinate their activity to support such learning. Using fMRI and a classic visual SL task, we investigated changes in whole-brain functional architecture as human female and male participants implicitly learned to associate pairs of images, and later, when predictions generated from learning were violated. By projecting individuals' patterns of cortical and subcortical functional connectivity onto a low-dimensional manifold space, we found that SL was associated with changes along a single neural dimension describing covariance across the visual-parietal and perirhinal cortex (PRC). During learning, we found regions within the visual cortex expanded along this dimension, reflecting their decreased communication with other networks, whereas regions within the dorsal attention network (DAN) contracted, reflecting their increased connectivity with higher-order cortex. Notably, when SL was interrupted, we found the PRC and entorhinal cortex, which did not initially show learning-related effects, now contracted along this dimension, reflecting their increased connectivity with the default mode and DAN, and decreased covariance with visual cortex. While prior research has linked SL to either broad cortical or medial temporal lobe changes, our findings suggest an integrative view, whereby cortical regions reorganize during association formation, while medial temporal lobe regions respond to their violation.