{"title":"A new diphenyl ether with insecticidal activity from the mangrove endophytic fungus <i>Aspergillus</i> sp. GXNU-DY2-12.","authors":"Meijing Tan, Shichao Ju, Fan He, Wenjun Li, Youquan Wei, Weifeng Xu, Ruiyun Yang, Xishan Huang","doi":"10.1080/14786419.2025.2476201","DOIUrl":null,"url":null,"abstract":"<p><p>A new diphenyl ether pseudopithoether C (<b>1</b>), and five known compounds (<b>2-6</b>) were purified from secondary metabolites of the <i>Aspergillus</i> sp. GXNU-DY2-12 cultured in the rice medium. The new structure was analysed by NMR, HR-ESI-MS, and X-ray single crystal diffractometer. Compound <b>1</b> showed potent acetylcholinesterase (AChE) - inhibiting activity and its IC<sub>50</sub> value was 1.02 μM. Notably, it demonstrated remarkable insecticidal efficacy against <i>Diaphorina citri Kuwayama</i>, achieving a mortality rate of 88% under standardised bioassay conditions.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2476201","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A new diphenyl ether pseudopithoether C (1), and five known compounds (2-6) were purified from secondary metabolites of the Aspergillus sp. GXNU-DY2-12 cultured in the rice medium. The new structure was analysed by NMR, HR-ESI-MS, and X-ray single crystal diffractometer. Compound 1 showed potent acetylcholinesterase (AChE) - inhibiting activity and its IC50 value was 1.02 μM. Notably, it demonstrated remarkable insecticidal efficacy against Diaphorina citri Kuwayama, achieving a mortality rate of 88% under standardised bioassay conditions.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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