Advanced CuMnCr-LDH modified glassy carbon electrode for simultaneous electrochemical quantification of cabotegravir and paracetamol in biological and pharmaceutical samples

Abstract

The simultaneous detection of antiviral and analgesic drugs in biological samples is critical for effective drug therapy monitoring. In this study, a novel electrochemical sensor was developed for the concurrent determination of the antiviral drug Cabotegravir (CABO) and the analgesic Paracetamol (PARA). The sensor was fabricated by modifying a glassy carbon electrode (GCE) with a CuMnCr-LDH nanocomposite, which served as an efficient electrocatalyst. The electrochemical properties of the modified electrode were characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The novel CuMnCr-LDH composite exhibits exceptional electrocatalytic activity due to its numerous active sites, reduced charge-transfer resistance, and rapid electron transfer. The sensor’s performance for simultaneous CABO and PARA detection was assessed using CV and differential pulse voltammetry (DPV) techniques. Under optimized conditions, the sensor demonstrated excellent sensitivity with linear ranges of 0.06–28.3 μM for CABO and 0.4–53 μM for PARA and detection limits (LOD) of 0.028 μM and 0.19 μM, respectively. Furthermore, the sensor demonstrated excellent reliability and accuracy when applied to pharmaceutical and biological samples, showcasing its potential for real-world applications in clinical and pharmaceutical settings.