{"title":"Peroxynitric acid decreases β-sheet and cytotoxicity of insulin amyloid","authors":"Yuito Murakami , Takahiro Watanabe , Satoshi Ikawa , Katsuhisa Kitano , Tamotsu Zako","doi":"10.1016/j.cplett.2025.142001","DOIUrl":null,"url":null,"abstract":"<div><div>Peroxynitric acid (PNA), a reactive nitrogen species, has attracted attention in the life science fields due to its unique properties such as bactericidal activity and safety. Herein, we demonstrated for the first time that PNA reduced β-sheet of insulin amyloids without changing their fibrillar morphology, and reduced their toxicity. It was also reported firstly that dark-field microscope can be used to observe amyloids. This finding may provide a chemical and physical basis to the development of new treatments using PNA for amyloid-related diseases.</div></div>","PeriodicalId":273,"journal":{"name":"Chemical Physics Letters","volume":"868 ","pages":"Article 142001"},"PeriodicalIF":3.1000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Physics Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0009261425001411","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Peroxynitric acid (PNA), a reactive nitrogen species, has attracted attention in the life science fields due to its unique properties such as bactericidal activity and safety. Herein, we demonstrated for the first time that PNA reduced β-sheet of insulin amyloids without changing their fibrillar morphology, and reduced their toxicity. It was also reported firstly that dark-field microscope can be used to observe amyloids. This finding may provide a chemical and physical basis to the development of new treatments using PNA for amyloid-related diseases.
期刊介绍：
Chemical Physics Letters has an open access mirror journal, Chemical Physics Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Chemical Physics Letters publishes brief reports on molecules, interfaces, condensed phases, nanomaterials and nanostructures, polymers, biomolecular systems, and energy conversion and storage.
Criteria for publication are quality, urgency and impact. Further, experimental results reported in the journal have direct relevance for theory, and theoretical developments or non-routine computations relate directly to experiment. Manuscripts must satisfy these criteria and should not be minor extensions of previous work.
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