Combothérapie par rituximab et anakinra dans le traitement d'une péricardite chronique compliquant une polyarthrite rhumatoïde

Abstract

Pericarditis is often an asymptomatic complication of rheumatoid arthritis. It rarely progresses towards tamponade or chronicity. There is little data on the therapeutic management of this serious complication. Recently, some rare data evaluating the place of biotherapy in rheumatoid pericarditis have been published. We report the observation of a patient with immunopositive rheumatoid arthritis escaping several lines of treatment who developed tamponade which recurred after surgical drainage. Only combotherapy with rituximab and anakinra allowed the induction of rheumatological remission and the disappearance of pericarditis.