Comparison of the characteristics of sedation using target-controlled infusion and manual infusion of propofol in patients undergoing lower limb surgery under spinal anaesthesia; a randomised controlled trial

Q2 Nursing Perioperative Care and Operating Room Management Pub Date : 2025-02-24 DOI:10.1016/j.pcorm.2025.100482

Pinki Kumari, Anju R. Bhalotra, Rahil Singh, Mona Arya, Shweta Dhiman

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引用次数: 0

Abstract

Background

Conscious sedation during spinal anaesthesia can be achieved by administering propofol using manual controlled infusions (MPI) or target-controlled infusions (TCI). We compared the characteristics of sedation with propofol administered by MPI and TCI in patients undergoing lower limb surgery under spinal anaesthesia.

Methods

A total of 60 patients aged 18–60 years with American Society of Anaesthesiologists physical status 1 and 2 who were scheduled for elective lower limb surgery of an anticipated duration of 1–2 h under spinal anaesthesia were enrolled. Participants were randomly allocated in 1:1 to either Group TCI or Group MPI to receive propofol sedation to maintain OAA/S 3. The primary outcome measure was the recovery time. Secondary outcomes were time to reach the desired level of sedation (OAA/S 3) and the total dose of propofol consumed.

Main results

The mean recovery time was 6.23 ± 1.63 min in the TCI group and 7.30 ± 1.44 min in the MPI group (p = 0.010). The total dose of propofol used in the TCI group (230.07 ± 83.77) was significantly higher than in the MPI group (162.33 ± 62.29) with a p = 0.001. A very strong positive correlation was observed between OAA/S and BIS in the TCI group (r = 0.969) as well as in the MPI group (r = 0.955) with a p < 0.001.

Conclusion

With the study design employed, TCI was associated with a faster recovery and MPI with less propofol consumption. There was a high correlation between OAA/S and BIS values.

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来源期刊

Perioperative Care and Operating Room Management Nursing-Medical and Surgical Nursing

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

56 days

期刊介绍： The objective of this new online journal is to serve as a multidisciplinary, peer-reviewed source of information related to the administrative, economic, operational, safety, and quality aspects of the ambulatory and in-patient operating room and interventional procedural processes. The journal will provide high-quality information and research findings on operational and system-based approaches to ensure safe, coordinated, and high-value periprocedural care. With the current focus on value in health care it is essential that there is a venue for researchers to publish articles on quality improvement process initiatives, process flow modeling, information management, efficient design, cost improvement, use of novel technologies, and management.