Synthesis, optical properties, theoretical calculations, and related applications of small molecule fluorescent probes

IF 3.3 3区物理与天体物理 Q2 OPTICS Journal of Luminescence Pub Date : 2025-03-06 DOI:10.1016/j.jlumin.2025.121177

Jinghua Zhang , Yue Tang , Xiaoqiang Tong , Qichuan Duan , Shi Jin , Jun Zheng , Guoliang Xie , Dingmei Qin , Shangrong Zhang , Deqian Huang , Feng Jin

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Abstract

Small molecule fluorescent probes are important chemical tools for studying the localization of fluorescent probes and their surrounding environmental characteristics in fields such as biochemistry, cell imaging, and materials science. Two novel fluorescent probes based on carbazole fluorophores were designed and synthesized in this study. The optical properties of P1 and P2 were studied by UV visible absorption spectroscopy, one-photon excited fluorescence spectroscopy, and two-photon excited fluorescence spectroscopy. Meanwhile, the results of cell imaging experiments demonstrate that P1 exhibits good cell permeability and low cell toxicity, and has excellent imaging and mitochondrial localization abilities in cells. In addition, detailed spectral analysis of P2 under acidic and alkaline conditions was conducted, revealing its acid-induced color-change property in solutions. Based on its acid-base sensing characteristics, P2 demonstrates potential applications in the field of anti-counterfeiting. The design and application of P1 and P2 provide valuable information for the development of more carbazole-based fluorescent probes.

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来源期刊

Journal of Luminescence 物理-光学

CiteScore

6.70

自引率

13.90%

发文量

850

审稿时长

3.8 months

期刊介绍： The purpose of the Journal of Luminescence is to provide a means of communication between scientists in different disciplines who share a common interest in the electronic excited states of molecular, ionic and covalent systems, whether crystalline, amorphous, or liquid. We invite original papers and reviews on such subjects as: exciton and polariton dynamics, dynamics of localized excited states, energy and charge transport in ordered and disordered systems, radiative and non-radiative recombination, relaxation processes, vibronic interactions in electronic excited states, photochemistry in condensed systems, excited state resonance, double resonance, spin dynamics, selective excitation spectroscopy, hole burning, coherent processes in excited states, (e.g. coherent optical transients, photon echoes, transient gratings), multiphoton processes, optical bistability, photochromism, and new techniques for the study of excited states. This list is not intended to be exhaustive. Papers in the traditional areas of optical spectroscopy (absorption, MCD, luminescence, Raman scattering) are welcome. Papers on applications (phosphors, scintillators, electro- and cathodo-luminescence, radiography, bioimaging, solar energy, energy conversion, etc.) are also welcome if they present results of scientific, rather than only technological interest. However, papers containing purely theoretical results, not related to phenomena in the excited states, as well as papers using luminescence spectroscopy to perform routine analytical chemistry or biochemistry procedures, are outside the scope of the journal. Some exceptions will be possible at the discretion of the editors.