Copolymers of Acrylamides and Acrylic Acid with Antiviral Activity

IF 1 4区 化学 Q4 POLYMER SCIENCE Polymer Science, Series B Pub Date : 2024-12-23 DOI:10.1134/S1560090424601377
E. F. Panarin, O. N. Zhuravskaya, A. V. Sitko, E. N. Vlasova, A. A. Shtro
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Abstract

Carboxylic polyelectrolytes, water-soluble copolymers of acrylic acid and N-substituted acrylamides, were synthesized for the first time by reactions in the chains of poly(acrylic anhydride) with aromatic amines. The structure, composition, and molecular weight characteristics of the copolymers were determined. The possibility of synthesizing alternating copolymers of acrylic acid was demonstrated. The copolymers of varying composition characterized by low cytotoxicity and activity against herpes simplex virus were prepared.

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具有抗病毒活性的丙烯酰胺和丙烯酸共聚物
首次在聚丙烯酸酐链上与芳香胺反应合成了丙烯酸与n -取代丙烯酰胺的水溶性共聚物羧基聚电解质。测定了共聚物的结构、组成和分子量特性。证明了合成丙烯酸交联共聚物的可能性。制备了具有低细胞毒性和抗单纯疱疹病毒活性的不同组成的共聚物。
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来源期刊
Polymer Science, Series B
Polymer Science, Series B 化学-高分子科学
CiteScore
1.80
自引率
8.30%
发文量
58
审稿时长
>0 weeks
期刊介绍: Polymer Science, Series B is a journal published in collaboration with the Russian Academy of Sciences. Series B experimental and theoretical papers and reviews dealing with the synthesis, kinetics, catalysis, and chemical transformations of macromolecules, supramolecular structures, and polymer matrix-based composites (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed
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