Effectiveness of the XBB.1.5 COVID-19 Vaccines Against SARS-CoV-2 Hospitalisation Among Adults Aged ≥ 65 Years During the BA.2.86/JN.1 Predominant Period, VEBIS Hospital Study, Europe, November 2023 to May 2024

IF 4.2 4区医学 Q1 INFECTIOUS DISEASES Influenza and Other Respiratory Viruses Pub Date : 2025-03-09 DOI:10.1111/irv.70081

Liliana Antunes, Madelyn Rojas-Castro, Marcos Lozano, Iván Martínez-Baz, Isabel Leroux-Roels, Maria-Louise Borg, Beatrix Oroszi, Margaret Fitzgerald, Ralf Dürrwald, Ligita Jancoriene, Ausenda Machado, Goranka Petrović, Mihaela Lazar, Lenka Součková, Sabrina Bacci, Jennifer Howard, Nuno Verdasca, Luca Basile, Jesús Castilla, Silke Ternest, Aušra Džiugytė, Gergő Túri, Roisin Duffy, Carolin Hackmann, Monika Kuliese, Verónica Gomez, Zvjezdana Lovrić Makarić, Alexandru Marin, Petr Husa, Nathalie Nicolay, Angela M. C. Rose, VEBIS SARI VE network team

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Abstract

We estimated the effectiveness of the adapted monovalent XBB.1.5 COVID-19 vaccines against PCR-confirmed SARS-CoV-2 hospitalisation during the BA.2.86/JN.1 lineage-predominant period using a multicentre test-negative case–control study in Europe. We included older adults (≥ 65 years) hospitalised with severe acute respiratory infection from November 2023 to May 2024. Vaccine effectiveness was 46% at 14–59 days and 34% at 60–119 days, with no effect thereafter. The XBB.1.5 COVID-19 vaccines conferred protection against BA.2.86 lineage hospitalisation in the first 4 months post-vaccination.

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XBB.1.5 COVID-19疫苗对≥65岁成人SARS-CoV-2住院治疗的有效性[j]主要时期，欧洲VEBIS医院研究，2023年11月至2024年5月

我们估计了适应单价XBB.1.5 COVID-19疫苗在BA.2.86/JN期间对pcr确认的SARS-CoV-2住院治疗的有效性。在欧洲进行的一项多中心检测阴性病例对照研究中发现1个谱系优势期。我们纳入了2023年11月至2024年5月期间因严重急性呼吸道感染住院的老年人（≥65岁）。疫苗在14-59天和60-119天的有效性分别为46%和34%，此后没有效果。XBB.1.5 COVID-19疫苗在接种后的头4个月内可防止BA.2.86谱系患者住院。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.