Branched Polymer Architecture for Modulating Interactions in Material-Bio Interface.

IF 4.1 4区医学 Q2 CELL & TISSUE ENGINEERING Tissue engineering and regenerative medicine Pub Date : 2025-06-01 Epub Date: 2025-03-08 DOI:10.1007/s13770-024-00699-1

Fahimeh Taghavimandi, Min Gyu Kim, Mingyu Lee, Kwangsoo Shin

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Abstract

Background: Branched polymers, including star, dendrimers, comb, and biomimetic polymers, are increasingly recognized for their potential in tissue engineering. Their unique architectures and functional properties contribute to enhanced mechanical strength, bioactivity, and adaptability of scaffolds and hydrogels.

Objective: This review explores the diverse applications of branched polymers in tissue engineering and regenerative medicine, emphasizing their role in mimicking the extracellular matrix (ECM) and modulating interactions at the material-bio interface. The structural features of branched polymers, including branching density and functional group distribution, are highlighted for their influence on drug delivery, mechanical properties, and cellular interactions.

Results: Branched polymers offer distinct advantages in tissue engineering: Star polymers: Provide tunable elasticity and facilitate long-range mechanical networking. Dendrimers: Enable precise functionalization for targeted drug delivery and cell signaling. Comb polymers: Enhance porosity and nutrient exchange in scaffolds. Biomimetic polymers: Mimic natural biological systems, promoting cellular adhesion, proliferation, and differentiation.

Conclusion: Branched polymers represent a versatile and promising platform for tissue engineering and regenerative medicine. Their ability to modulate biological interactions and adapt to diverse functional requirements underscores their potential to advance the field.

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用于调节材料-生物界面相互作用的支化聚合物结构。

背景：支链聚合物，包括星形聚合物、树突状聚合物、梳状聚合物和仿生聚合物，因其在组织工程中的潜力而越来越受到人们的认可。其独特的结构和功能特性有助于增强支架和水凝胶的机械强度、生物活性和适应性。目的：综述了支链聚合物在组织工程和再生医学中的应用，重点介绍了支链聚合物在模拟细胞外基质（ECM）和调节材料-生物界面相互作用方面的作用。支化聚合物的结构特征，包括支化密度和官能团分布，突出了它们对药物传递、机械性能和细胞相互作用的影响。结果：支链聚合物在组织工程中具有明显的优势：星形聚合物：提供可调的弹性和促进远程机械网络。树突状分子：实现靶向药物传递和细胞信号的精确功能化。梳状聚合物：增强支架的孔隙度和营养交换。仿生聚合物：模仿自然生物系统，促进细胞粘附、增殖和分化。结论：支链聚合物在组织工程和再生医学领域具有广阔的应用前景。它们调节生物相互作用和适应不同功能需求的能力强调了它们推进该领域的潜力。

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来源期刊

Tissue engineering and regenerative medicine CELL & TISSUE ENGINEERING-ENGINEERING, BIOMEDICAL

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Tissue Engineering and Regenerative Medicine (Tissue Eng Regen Med, TERM), the official journal of the Korean Tissue Engineering and Regenerative Medicine Society, is a publication dedicated to providing research- based solutions to issues related to human diseases. This journal publishes articles that report substantial information and original findings on tissue engineering, medical biomaterials, cells therapy, stem cell biology and regenerative medicine.