{"title":"Disrupting cholesterol homeostasis in T cells boosts antitumour responses","authors":"Kelly T. Kennewick, Steven J. Bensinger","doi":"10.1038/s42255-025-01240-x","DOIUrl":null,"url":null,"abstract":"A new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring cholesterol metabolism, Elovl1-depleted T cells gain increased fitness and synergize with anti-PD-1 therapy to enhance antitumour responses.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"441-443"},"PeriodicalIF":20.8000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42255-025-01240-x.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature metabolism","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s42255-025-01240-x","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
A new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring cholesterol metabolism, Elovl1-depleted T cells gain increased fitness and synergize with anti-PD-1 therapy to enhance antitumour responses.
期刊介绍：
Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.
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