Palladium/phosphoramidite-selenide-catalyzed enantioselective allylic etherification reaction

Abstract

Several chiral phosphoramidite-selenide ligands were employed in the palladium-catalyzed asymmetric allylic etherification of 1,3-diarylpropenyl acetate. Under the optimal reaction conditions, a wide range of O-nucleophiles such as benzyl alcohol, methanol, cinnamyl alcohol and so on, were well tolerated to give the products in good yields (up to 93%) with moderate enantioselectivities (up to 85% ee).