Alexander F Makarchikov, Pierre Wins, Lucien Bettendorff
{"title":"BIOCHEMICAL AND MEDICAL ASPECTS OF VITAMIN B<sub>1</sub> RESEARCH.","authors":"Alexander F Makarchikov, Pierre Wins, Lucien Bettendorff","doi":"10.1016/j.neuint.2025.105962","DOIUrl":null,"url":null,"abstract":"<p><p>Vitamin B<sub>1</sub> is an indispensable food factor for the human and animal body. In animals, vitamin B<sub>1</sub> is found in the form of thiamine and its phosphate esters - thiamine mono-, di- and triphosphate, as well as an adenylated derivative - adenosine thiamine triphosphate. At present, the only vitamin B<sub>1</sub> form with biochemical functions being elucidated is thiamine diphosphate, which serves as a coenzyme for several important enzymes involved in carbohydrate, amino acid, fatty acid and energy metabolism. Here we review the latest developments in the field of vitamin B<sub>1</sub> research in animals. Transport, metabolism and biological role of thiamine and its derivatives are considered as well as the involvement of vitamin B<sub>1</sub>-dependent processes in human diseases and its therapeutic issues, a field that has gained momentum with several important recent developments.</p>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":" ","pages":"105962"},"PeriodicalIF":4.4000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemistry international","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuint.2025.105962","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Vitamin B1 is an indispensable food factor for the human and animal body. In animals, vitamin B1 is found in the form of thiamine and its phosphate esters - thiamine mono-, di- and triphosphate, as well as an adenylated derivative - adenosine thiamine triphosphate. At present, the only vitamin B1 form with biochemical functions being elucidated is thiamine diphosphate, which serves as a coenzyme for several important enzymes involved in carbohydrate, amino acid, fatty acid and energy metabolism. Here we review the latest developments in the field of vitamin B1 research in animals. Transport, metabolism and biological role of thiamine and its derivatives are considered as well as the involvement of vitamin B1-dependent processes in human diseases and its therapeutic issues, a field that has gained momentum with several important recent developments.
期刊介绍：
Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
