{"title":"TRTBee: a standalone calculator for time-reinforced toxicity according to European Food Safety Authority honeybee guidelines.","authors":"Neil Sherborne, Helen M Thompson, Roman Ashauer","doi":"10.1093/etojnl/vgaf061","DOIUrl":null,"url":null,"abstract":"<p><p>The revised European Food Safety Authority (EFSA) guidance document for the risk assessment of plant protection products on honeybees requires an assessment of time-reinforced toxicity (TRT) using toxicokinetic-toxicodynamic modeling. Although there are user-friendly software options available for this modeling, it is not specialized for this new application; therefore, conducting the TRT assessment still requires additional manual calculations. Here, we present TRTBee, a new, freely available tool that is capable of automatically performing all stages of the TRT assessment. The tool is based on robust and well-known algorithms. We conclude with a brief discussion of the open problems that still exist within the EFSA scheme.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1497-1502"},"PeriodicalIF":2.8000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Toxicology and Chemistry","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1093/etojnl/vgaf061","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The revised European Food Safety Authority (EFSA) guidance document for the risk assessment of plant protection products on honeybees requires an assessment of time-reinforced toxicity (TRT) using toxicokinetic-toxicodynamic modeling. Although there are user-friendly software options available for this modeling, it is not specialized for this new application; therefore, conducting the TRT assessment still requires additional manual calculations. Here, we present TRTBee, a new, freely available tool that is capable of automatically performing all stages of the TRT assessment. The tool is based on robust and well-known algorithms. We conclude with a brief discussion of the open problems that still exist within the EFSA scheme.
期刊介绍：
The Society of Environmental Toxicology and Chemistry (SETAC) publishes two journals: Environmental Toxicology and Chemistry (ET&C) and Integrated Environmental Assessment and Management (IEAM). Environmental Toxicology and Chemistry is dedicated to furthering scientific knowledge and disseminating information on environmental toxicology and chemistry, including the application of these sciences to risk assessment.[...]
Environmental Toxicology and Chemistry is interdisciplinary in scope and integrates the fields of environmental toxicology; environmental, analytical, and molecular chemistry; ecology; physiology; biochemistry; microbiology; genetics; genomics; environmental engineering; chemical, environmental, and biological modeling; epidemiology; and earth sciences. ET&C seeks to publish papers describing original experimental or theoretical work that significantly advances understanding in the area of environmental toxicology, environmental chemistry and hazard/risk assessment. Emphasis is given to papers that enhance capabilities for the prediction, measurement, and assessment of the fate and effects of chemicals in the environment, rather than simply providing additional data. The scientific impact of papers is judged in terms of the breadth and depth of the findings and the expected influence on existing or future scientific practice. Methodological papers must make clear not only how the work differs from existing practice, but the significance of these differences to the field. Site-based research or monitoring must have regional or global implications beyond the particular site, such as evaluating processes, mechanisms, or theory under a natural environmental setting.
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