{"title":"The ratio of perirenal fat thickness to renal parenchymal thickness, a novel indicator of fat accumulation associated with kidney stones.","authors":"Dekai Hu, Guoxiang Li, Defeng Ge, Leilei Ke, Hongmin Shu, Yang Chen, Zongyao Hao","doi":"10.1186/s12944-025-02497-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome, identified by increased visceral fat accumulation, is notably linked to a heightened risk of nephrolithiasis. Despite this, the influence of the perirenal fat thickness relative to renal parenchymal thickness on kidney stones (KS) development remains ambiguous. This study investigated the clinical characteristics of perirenal fat on both the left and right sides and explored the association between the aforementioned ratio and KS.</p><p><strong>Methods: </strong>The study enrolled 161 participants who underwent computed tomography (CT) scans. In this study, kidneys were segregated into two categories based on the presence of stones: stone-bearing and non-stone-bearing for both the left and right kidneys. Perirenal fat parameters were extracted from the imaging workstation database. Both univariate and multivariate logistic regression analyses were conducted to explore the correlation between metrics related to perirenal fat and the occurrence of KS.</p><p><strong>Results: </strong>Among the 161 participants, significant variations in perirenal fat were observed between the left and right kidneys, as well as between genders. Subsequent to adjustments for several confounding variables, the multivariable logistic regression model demonstrated a significant correlation between the ratio of perirenal fat thickness to renal parenchymal thickness and stone bearing kidney (P < 0.001).</p><p><strong>Conclusions: </strong>The ratio of perirenal fat thickness to renal parenchymal thickness was significantly correlated with kidney stones.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"86"},"PeriodicalIF":3.9000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887230/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-025-02497-7","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Metabolic syndrome, identified by increased visceral fat accumulation, is notably linked to a heightened risk of nephrolithiasis. Despite this, the influence of the perirenal fat thickness relative to renal parenchymal thickness on kidney stones (KS) development remains ambiguous. This study investigated the clinical characteristics of perirenal fat on both the left and right sides and explored the association between the aforementioned ratio and KS.
Methods: The study enrolled 161 participants who underwent computed tomography (CT) scans. In this study, kidneys were segregated into two categories based on the presence of stones: stone-bearing and non-stone-bearing for both the left and right kidneys. Perirenal fat parameters were extracted from the imaging workstation database. Both univariate and multivariate logistic regression analyses were conducted to explore the correlation between metrics related to perirenal fat and the occurrence of KS.
Results: Among the 161 participants, significant variations in perirenal fat were observed between the left and right kidneys, as well as between genders. Subsequent to adjustments for several confounding variables, the multivariable logistic regression model demonstrated a significant correlation between the ratio of perirenal fat thickness to renal parenchymal thickness and stone bearing kidney (P < 0.001).
Conclusions: The ratio of perirenal fat thickness to renal parenchymal thickness was significantly correlated with kidney stones.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
