Summary of a Consensus Conference on the Management of Highly Sensitized Multiorgan Transplant Candidates.

IF 6.9 2区医学 Q1 MEDICINE, GENERAL & INTERNAL Mayo Clinic proceedings Pub Date : 2025-03-07 DOI:10.1016/j.mayocp.2025.01.012

Timucin Taner, Scott W Biggins, Nathan Cummins, Richard C Daly, Allan B Dietz, Juliet Emamaullee, Manish J Gandhi, Julie K Heimbach, Jignesh K Patel, Naveen L Pereira, Andrew Rosenbaum, Alberto Sanchez-Fueyo, Alexandra Shingina, Mark D Stegall, Mauricio A Villavicencio Theoduloz, Joyce W Wald, Sudhir S Kushwaha

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Abstract

The number of highly sensitized patients in need of a multiorgan transplant is increasing. Criteria informing their transplant candidacy, approaches to management on the waitlist, and protocols related to alloantibody monitoring vary widely. We convened a consensus conference to discuss these different practices in the United States and the United Kingdom and to review the contemporary outcomes of these challenging cases. A detailed analysis of the data regarding the liver allografts' immunoprotective effect on simultaneously transplanted other organs was also completed, and the prospect of the use of liver allografts primarily to facilitate transplantation of highly sensitized patients in need of other organs was discussed. The ethical and allocation-related issues about such prospect were debated with a goal to standardize the approach and provide an evidence-based pathway for pre-, peri-, and post-transplantation management for the highly sensitized multiorgan transplantation candidate.

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来源期刊

Mayo Clinic proceedings 医学-医学：内科

CiteScore

16.80

自引率

1.10%

发文量

383

审稿时长

37 days

期刊介绍： Mayo Clinic Proceedings is a premier peer-reviewed clinical journal in general medicine. Sponsored by Mayo Clinic, it is one of the most widely read and highly cited scientific publications for physicians. Since 1926, Mayo Clinic Proceedings has continuously published articles that focus on clinical medicine and support the professional and educational needs of its readers. The journal welcomes submissions from authors worldwide and includes Nobel-prize-winning research in its content. With an Impact Factor of 8.9, Mayo Clinic Proceedings is ranked #20 out of 167 journals in the Medicine, General and Internal category, placing it in the top 12% of these journals. It invites manuscripts on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.

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