Mayo Clinic proceedings最新文献

英文中文

Yellow Urticaria. 黄色的荨麻疹。

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-10 DOI: 10.1016/j.mayocp.2025.10.019

Yi-Kuan Chiang, Sheng-Hsiang Ma

引用次数: 0

Mycosis Fungoides With Large-Cell Transformation and CD30 Positivity. 具有大细胞转化和CD30阳性的蕈样真菌病。

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-07 DOI: 10.1016/j.mayocp.2025.10.004

Yen T H Le, Julia S Lehman, Emma F Johnson

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Takayasu Arteritis Presenting as Stress-Induced Chest Pain. 高须动脉炎表现为应激性胸痛。

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-06 DOI: 10.1016/j.mayocp.2025.10.008

Yumiko Yoshida, Yuichi Takahashi, Yuichiro Mine, Toshio Naito

引用次数: 0

Shortage of Obesity Medicine Specialists in the United States. 美国肥胖医学专家短缺。

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-05 DOI: 10.1016/j.mayocp.2025.10.015

Simar Singh Bajaj, Shreyas Teegala, Fatima Cody Stanford

引用次数: 0

Association of Body Fatness With Hypertension, Dyslipidemia, and Myocardial Infarction in a Multinational Pooled Cohort. 体胖与高血压、血脂异常和心肌梗死在一项跨国合并队列研究中的关系

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-05 DOI: 10.1016/j.mayocp.2025.10.014

Vivek Kumar Prasad, Chibueze Ogbonnaya, Hannah Oh, Andrew Atkin, Madison Kindred, Min-Jeong Shin, Dahyun Park, Jin Eui Kim, Mike Loosemore, Vartika Saxena, Ryan Porter, Courtney Kipps, Jason Jaggers, Xuemei Sui, Carl J Lavie, Mark Hamer

Objective: To investigate the association of dual-energy X-ray absorptiometry-measured body fat percentage (BF%) and trunk fat mass index (TFMI) with hypertension (HTN), dyslipidemia, and myocardial infarction (MI).

Methods: The relationship between body fat parameters and cardiovascular disease (CVD) was studied across individuals in the same body mass index (BMI) group. Data from the UK Biobank, a multicountry large population-based study, and the US and Korean National Health and Nutrition Examination Surveys, generating nationally representative samples, were pooled and harmonized. This cross-sectional analysis included 30,520 women and 27,244 men aged 40 years or older.

Results: A significant increase in relative risks (RRs) of HTN across BF% quintiles was seen in men with normal weight, overweight, and obesity (P≤.01) and in normal weight women (P<.001). The RRs of dyslipidemia for normal weight and overweight men and women significantly increased across BF% quintiles (P≤.002). The RRs of MI did not exhibit a trend across BF% quintiles for participants within various BMI categories. The RRs of HTN and dyslipidemia significantly increased across TFMI quintiles for men and women with normal weight, overweight, and obesity (P≤.007). In men with normal weight, overweight, and obesity, the RRs of MI significantly increased across TFMI quintiles (P≤.03). However, no trend was displayed in the RRs of MI for women in any BMI group.

Conclusion: This analysis revealed a positive association of dual-energy X-ray absorptiometry-measured body fat parameters with CVDs for individuals in a specific BMI group. The findings highlight a need for policy changes to include directly measured body fatness in assessing CVD risk.

目的：探讨双能x线体脂率（BF%）和躯干脂肪质量指数（TFMI）与高血压（HTN）、血脂异常和心肌梗死（MI）的关系。方法：在同一体重指数（BMI）组中研究体脂参数与心血管疾病（CVD）的关系。来自英国生物银行（一项多国大型人口研究）的数据，以及美国和韩国国家健康和营养检查调查（产生具有全国代表性的样本）的数据进行了汇总和协调。这项横断面分析包括30,520名女性和27,244名年龄在40岁或以上的男性。结果：在体重正常、超重和肥胖的男性以及体重正常的女性中，HTN的相对风险（rr）在BF%五分位数中显著增加（P≤0.01）。结论：该分析揭示了双能x线吸收仪测量的体脂参数与特定BMI组个体的cvd呈正相关。研究结果强调了在评估心血管疾病风险时需要改变政策，包括直接测量身体脂肪。

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引用次数: 0

Diagnostic Agreement Between Coronary Flow Reserve Measured by Doppler and Thermodilution Techniques. 多普勒测量冠状动脉血流储备与热稀释技术诊断的一致性。

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-05 DOI: 10.1016/j.mayocp.2025.09.011

Naba Farooqui, Amr Moustafa, Timothy D Henry, Amir Lerman, Claire E Raphael

引用次数: 0

Impact of Tumor Burden and Cardiac Factors on Survival After Valve Surgery for Carcinoid Heart Disease 肿瘤负荷和心脏因素对类癌心脏病瓣膜手术后生存的影响。

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-01 DOI: 10.1016/j.mayocp.2025.01.026

Tedy Sawma MD , Hartzell V. Schaff MD , Gokce Belge Bilgin MD , Anita Zheng MD , Defne Gunes Ergi MD , Austin Todd MS , A. Tuba Kendi MD , Sushil Allen Luis MD , Cornelius A. Thiels DO, MBA , Thorvardur R. Halfdanarson MD , Patricia A. Pellikka MD , Heidi M. Connolly MD , Juan A. Crestanello MD

Objective

To evaluate the association of preoperative cardiac status and tumor characteristics with long-term survival after valve surgery for carcinoid heart disease (CHD).

Methods

A retrospective review was conducted of patients surgically treated for CHD at our institution between 2000 and 2023.

Results

A total of 168 patients (median age, 63.2 years; 48.2% women) with CHD who underwent valvular surgery from 2000 to 2023 were included. The primary site of the neuroendocrine tumor was the small bowel in 89.3% of the patients. All patients had liver metastasis, with 31% of the patients having more than 75% involvement of the liver parenchyma, and 28% had bone metastases. Tricuspid valve replacement was performed in 98.2%, pulmonary valve replacement in 79.2%, and both in 78.6%. Operative mortality was 6%. After a median follow-up of 8.3 years, median survival was 2.9 (2.2 to 4.1) years (5-year survival was 34.1% for the overall cohort, 16.2% for patients with more than 75% liver metastasis, and 13.1% for those with bone metastases). Independent predictors of long-term mortality included more than 75% metastatic liver involvement (hazard ratio [HR], 1.5; 95% CI, 1.1 to 2.3), presence of bone metastases (HR, 2.0; 95% CI, 1.2 to 3.0), New York Heart Association class III or IV (HR, 2.3; 95% CI, 1.5 to 3.6), and severe right ventricular dysfunction (HR, 3.3; 95% CI, 1.4 to 7.6).

Conclusion

Valve surgery in patients with CHD relieves symptoms of right-sided heart failure. However, long-term survival is limited in patients with significant metastatic liver burden, bone metastases, or severe right ventricular dysfunction, underscoring the importance of incorporating these prognostic factors into preoperative risk assessment.

目的：探讨类癌性心脏病（CHD）瓣膜手术后术前心脏状态和肿瘤特征与长期生存的关系。方法：回顾性分析我院2000年至2023年手术治疗冠心病的患者。结果：共168例患者(中位年龄63.2岁；2000年至2023年间接受过瓣膜手术的冠心病患者（48.2%）被纳入研究对象。89.3%的患者神经内分泌肿瘤原发部位为小肠。所有患者均有肝转移，其中31%的患者肝实质受累超过75%，28%的患者有骨转移。三尖瓣置换术占98.2%，肺动脉瓣置换术占79.2%，两者均行78.6%。手术死亡率为6%。中位随访8.3年后，中位生存期为2.9年（2.2 - 4.1）年（整个队列的5年生存率为34.1%，肝转移超过75%的患者为16.2%，骨转移患者为13.1%）。长期死亡率的独立预测因素包括超过75%的转移性肝脏受累(危险比[HR]， 1.5；95% CI, 1.1 - 2.3)，存在骨转移(HR, 2.0；95% CI, 1.2 - 3.0)，纽约心脏协会III级或IV级(HR, 2.3；95% CI, 1.5 - 3.6)和严重的右心室功能障碍(HR, 3.3；95% CI, 1.4 ~ 7.6)。结论：冠心病患者行瓣膜手术可减轻右侧心力衰竭症状。然而，有显著转移性肝负担、骨转移或严重右心室功能障碍的患者的长期生存率有限，这强调了将这些预后因素纳入术前风险评估的重要性。

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引用次数: 0

Highlights from the Current Issue – Audiovisual Summary 从当前问题的亮点-视听摘要

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-01 DOI: 10.1016/j.mayocp.2025.12.007

Karl A. Nath MBChB

引用次数: 0

Building Artificial Intelligence and Data Literacy Across the Health Care Research Workforce in the Mayo Clinic Center for Clinical and Translational Science: Why It Matters and What We Are Doing About It 在梅奥临床和转化科学中心的医疗保健研究人员中建立人工智能和数据素养：为什么它很重要以及我们正在做些什么

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-01 DOI: 10.1016/j.mayocp.2025.11.008

Jaleh Zand PhD , Milovan Suvakov PhD , Shauna M. Overgaard PhD , Chester G. Kozikowski MEd , Ryan C. Jimison MEd , Kristina B. Nelson MS , Carmen J. Silvano , Laura M. Meiners MBA , Jungwei W. Fan PhD , Kate E. Schultz PhD , Rickey E. Carter PhD , Mark L. Wieland MD, MPH , Christi A. Patten PhD , Sagar B. Dugani MD, PhD, MPH , Jenny A. Weis MAN , John D. Poe MBA , David R. Holmes III PhD , Leigh G. Griffiths MRCVS, PhD , Heidi L. Dieter MBA , Young J. Juhn MD, MPH , Vesna D. Garovic MD, PhD

引用次数: 0

Retirement: Fostering Physician Well-being Over the Career Life Cycle 退休：在职业生命周期中培养医生的幸福感。

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings

Pub Date : 2026-01-01 DOI: 10.1016/j.mayocp.2025.05.027

Kirk J. Brower MD , Iris F. Litt MD , Tait D. Shanafelt MD

This manuscript is the last chapter in a series of 5 articles considering physician well-being during the course of a career. It focuses on the retirement stage, which follows planning for retirement and deciding when and how to retire. We view retirement as a process, characterized by recalibrating professional and personal activities while maintaining a sense of purpose and meaning in life. Some retirees may continue to work in medicine by seeing patients part-time or mentoring medical students, residents, and junior colleagues. Others may leave their lifelong work and seek joy and meaning in travel, spending time with family and friends, volunteering, and developing their personal interests and activities. Ideally, well-being in retirement includes having sufficient energy for activities and relationships that are meaningful, provide purpose, and are enjoyable. Stress during retirement usually shifts from occupational concerns to personal challenges with professional identity, caring for family and friends, maintaining one’s health, and relationship losses. Programs that specifically support retired physicians exist at some large health systems and select academic centers, which can complement resources provided by general medical associations and specialty societies. These can serve as models for other medical centers and a foundation for extending and expanding support to retired physicians.

这份手稿是在一系列的5篇文章的最后一章考虑医生的福祉在职业生涯的过程中。它侧重于退休阶段，这是继退休计划和决定何时以及如何退休之后的阶段。我们认为退休是一个过程，其特点是重新调整职业和个人活动，同时保持生活的使命感和意义。一些退休人员可能会继续从事医学工作，兼职看病或指导医学生、住院医生和初级同事。其他人可能会离开他们的终身工作，在旅行中寻找快乐和意义，与家人和朋友共度时光，做志愿者，发展他们的个人兴趣和活动。理想情况下，退休后的幸福生活包括有足够的精力从事有意义的、有目的的、令人愉快的活动和人际关系。退休期间的压力通常从职业问题转移到个人挑战，包括职业身份、照顾家人和朋友、保持健康和失去关系。一些大型医疗系统和一些学术中心都有专门支持退休医生的项目，这些项目可以补充普通医学协会和专业协会提供的资源。这可以作为其他医疗中心的榜样，并为扩大和扩大对退休医生的支持奠定基础。

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