{"title":"The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis.","authors":"Peng Zhou, Jie Yu, Bingmei Yan","doi":"10.1515/med-2024-1135","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the serum levels of interleukin (IL)-17A in patients with traumatic bowel rupture and its clinical significance, particularly its correlation with inflammatory cytokines, preoperative severity, and postoperative prognosis.</p><p><strong>Methods: </strong>A total of 104 patients with traumatic bowel rupture admitted to Ruian People's Hospital between February 2021 and June 2024 were included in this prospective observational study. All patients underwent standard surgical treatment for traumatic bowel rupture at our hospital. Serum levels of IL-17A, IL-6, tumor necrosis factor-alpha, and C-reactive protein were measured at various time points using enzyme-linked immunosorbent assay. Clinical data and demographics were collected. Patients were followed up for 3 months post-discharge.</p><p><strong>Results: </strong>The study found significantly higher levels of IL-17A and IL-6 in patients with an injury severity score (ISS) of ≥16 compared to those with an ISS of <16 (<i>p</i> < 0.05). Serum IL-17A levels were particularly elevated in patients with poor prognosis (<i>p</i> < 0.05). Of particular importance, receiver operating characteristic curve analysis demonstrated that serum IL-17A levels at 72 h post-surgery had predictive value for poor prognosis, with an area under the curve of 0.773, a cutoff value of 41.75 pg/mL, a sensitivity of 62.2%, and a specificity of 83.6%. Logistic regression analysis identified elevated IL-17 levels at 72 h post-surgery as a significant risk factor for poor prognosis (odds ratio = 1.273, 95% confidence interval: 1.115-1.453, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>In summary, our study highlights the significant potential of serum IL-17A as a biomarker for predicting poor prognosis in patients with traumatic bowel rupture post-surgery, suggesting its utility in clinical assessment and potential as a therapeutic target.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241135"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889506/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/med-2024-1135","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This study aimed to investigate the serum levels of interleukin (IL)-17A in patients with traumatic bowel rupture and its clinical significance, particularly its correlation with inflammatory cytokines, preoperative severity, and postoperative prognosis.
Methods: A total of 104 patients with traumatic bowel rupture admitted to Ruian People's Hospital between February 2021 and June 2024 were included in this prospective observational study. All patients underwent standard surgical treatment for traumatic bowel rupture at our hospital. Serum levels of IL-17A, IL-6, tumor necrosis factor-alpha, and C-reactive protein were measured at various time points using enzyme-linked immunosorbent assay. Clinical data and demographics were collected. Patients were followed up for 3 months post-discharge.
Results: The study found significantly higher levels of IL-17A and IL-6 in patients with an injury severity score (ISS) of ≥16 compared to those with an ISS of <16 (p < 0.05). Serum IL-17A levels were particularly elevated in patients with poor prognosis (p < 0.05). Of particular importance, receiver operating characteristic curve analysis demonstrated that serum IL-17A levels at 72 h post-surgery had predictive value for poor prognosis, with an area under the curve of 0.773, a cutoff value of 41.75 pg/mL, a sensitivity of 62.2%, and a specificity of 83.6%. Logistic regression analysis identified elevated IL-17 levels at 72 h post-surgery as a significant risk factor for poor prognosis (odds ratio = 1.273, 95% confidence interval: 1.115-1.453, p < 0.001).
Conclusion: In summary, our study highlights the significant potential of serum IL-17A as a biomarker for predicting poor prognosis in patients with traumatic bowel rupture post-surgery, suggesting its utility in clinical assessment and potential as a therapeutic target.
期刊介绍:
Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.