Reliability of Ki67-Labeling Index in Core Needle Biopsy Specimens of ER+/HER2- Breast Cancers.

IF 3.4 4区医学 Q2 PATHOLOGY Pathology International Pub Date : 2025-05-01 Epub Date: 2025-03-10 DOI:10.1111/pin.70005

Yumi Fukaya, Makoto Wakahara, Keiko Hosoya, Naoko Nouchi, Yoshihisa Umekita

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Abstract

The reliability of Ki67-labeling index (LI) in core needle biopsy (CNB) of ER+/HER2- invasive breast carcinoma (IBC) and factors affecting the discordance of Ki67-LI between CNB and surgical resection (SR) remain unsolved. We aimed to elucidate factors influencing the discordance of Ki67-LI between CNB and SR to classify ER+/HER2- IBC into luminal A-like (LumA) and luminal B-like (LumB). The cohort included 326 ER+/HER2- IBCs available with Ki67-LI data at both CNB and SR specimens. Survival analysis was performed on 122 patients. Spearman's rank correlation coefficient of Ki67-LI between them was 0.683. The log-rank test showed that patients with ER+/HER2- IBC with ≥ 20% Ki67-LI at CNB (p < 0.001) and SR specimens (p < 0.001) had significantly shorter disease-free survival. In multivariate analysis, a negative PgR (p = 0.002) and > 2 cm pathological tumor size (p < 0.001) had the most significant effect on the discordance of Ki67-LI between CNB and SR at 20% and 30% cutoffs, respectively. Histological grade III had a significant effect on the concordance between them (p = 0.01) at 20% cutoff. Ki67-LI assessment in CNB may be useful for classifying ER+/HER2- IBC into LumA and LumB with caution of some prognostic factors and cutoffs.

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ki67标记指数在ER+/HER2-乳腺癌针芯活检标本中的可靠性

对于ER+/HER2-浸润性乳腺癌（IBC）核心针活检（CNB）中ki67 -标记指数（LI）的可靠性以及影响Ki67-LI在CNB和手术切除（SR）之间不一致的因素，目前尚不清楚。我们旨在阐明影响CNB和SR之间Ki67-LI不一致的因素，将ER+/HER2- IBC分为luminal A-like （LumA）和luminal B-like （LumB）。该队列包括326例在CNB和SR标本中具有Ki67-LI数据的ER+/HER2- IBCs。对122例患者进行生存分析。两者间Ki67-LI的Spearman秩相关系数为0.683。log-rank检验显示，ER+/HER2- IBC患者在CNB时Ki67-LI≥20% （p 2cm病理肿瘤大小）

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来源期刊

Pathology International 医学-病理学

CiteScore

4.50

自引率

4.50%

发文量

102

审稿时长

12 months

期刊介绍： Pathology International is the official English journal of the Japanese Society of Pathology, publishing articles of excellence in human and experimental pathology. The Journal focuses on the morphological study of the disease process and/or mechanisms. For human pathology, morphological investigation receives priority but manuscripts describing the result of any ancillary methods (cellular, chemical, immunological and molecular biological) that complement the morphology are accepted. Manuscript on experimental pathology that approach pathologenesis or mechanisms of disease processes are expected to report on the data obtained from models using cellular, biochemical, molecular biological, animal, immunological or other methods in conjunction with morphology. Manuscripts that report data on laboratory medicine (clinical pathology) without significant morphological contribution are not accepted.