Characterization of scorpion envenoming in children care for a poisoning control center

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY Toxicon Pub Date : 2025-03-05 DOI:10.1016/j.toxicon.2025.108305
Raul Henrique Tonin dos Santos , Alberto Durán González , Camilo Molino Guidoni , Jéssica Vertuan Rufino , Rafaele Maria Tirolla , Edmarlon Girotto
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Abstract

Objective

To analyse the clinical and epidemiological factors associated with the toxicological events of scorpion envenomation in children aged 0–11 years followed at a Centre for Toxicological Information and Assistance (CIATox).

Methods

A descriptive study was conducted of children treated at the CIATox of the University Hospital of Londrina, Paraná, Brazil, from 2017 to 2022. Collected data included sociodemographic and clinical data, as well as data regarding the toxicological event. The dependent variable was hospitalization with a minimum duration of 24 h. For the association analyses, Poisson regression with logistic variance was used, with calculation of the relative risk (RR) and 95% confidence interval (95% CI).

Results

In total, 450 cases were analysed, with an increase in the number of cases over the years, and predominance of accidents caused by Tityus serrulatus (48.7%). The main local symptoms were pain and erythema/hyperaemia, and the main systemic symptoms were tachycardia, vomiting and generalized sweating. Antiscorpion serum or antiarachnidic serum was required for 10.9% of the patients. Hospitalization was observed in 8.4% of the cases, which was higher in children stung by T. serrulatus (RR = 11.34; 95% CI: 3.46–37.18; p < 0.001), aged 4 years or younger (OR = 2.13; 95% CI: 1.15–3.95; p = 0.016), and time between sting and CIATox treatment of 3 h or more (OR = 2.53; 95% CI: 1.20–5.35; p = 0.015).

Conclusions

The results indicate that pain, erythema/hypearemia, tachycardia, vomiting and sweating are the main clinical manifestations. Demographic, agent-related, and exposure-related factors were associated with patient hospitalization.

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来源期刊
Toxicon
Toxicon 医学-毒理学
CiteScore
4.80
自引率
10.70%
发文量
358
审稿时长
68 days
期刊介绍: Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.
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