A Retrospective Cohort Study Using Latent Growth Curve Models for Children With a Diagnosis of Asthma

IF 1.8 4区医学 Q2 HEALTH POLICY & SERVICES Journal of Pediatric Health Care Pub Date : 2025-07-01 Epub Date: 2025-03-08 DOI:10.1016/j.pedhc.2025.02.003

Ji-Mei Wu MSN, RN, Ji-Hong Wu MSN, RN, Dan Liu MD, Xia Qin BSN, RN, Tu-Hong Yang BSN, RN

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Abstract

Introduction

This study examined lung function trajectory (FEV1 % predicted) in children with asthma and explored the influence of sex and asthma control on these trajectories.

Methods

A retrospective cohort study used a latent growth curve model (LGCM) to analyze the FEV1 trajectory in children with asthma.

Results

FEV1 followed a quadratic trajectory with significant individual variability. Males exhibited a significantly slower rate of FEV1 change compared to females (estimate = −1.029, p < .001) but a higher acceleration rate (estimate = 0.269, p < .001). Improved asthma control was associated with a significant enhancement in FEV1 over time (p < .01).

Discussion

FEV1 growth followed a curvilinear trajectory, marked by gradual deceleration. Males had slower initial growth but greater acceleration. Asthma control significantly influenced lung function improvement.

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使用潜在生长曲线模型对诊断为哮喘的儿童进行回顾性队列研究。

本研究检查了哮喘儿童的肺功能轨迹（预测FEV1 %），并探讨了性别和哮喘控制对这些轨迹的影响。方法：采用潜伏生长曲线模型（LGCM）进行回顾性队列研究，分析哮喘患儿FEV1的变化轨迹。结果：FEV1呈二次曲线，个体差异显著。男性的FEV1变化率明显低于女性（估计= -1.029,p < .001），但加速速率更高（估计= 0.269,p < .001）。随着时间的推移，哮喘控制的改善与FEV1的显著增强相关（p < 0.01）。讨论：FEV1的增长遵循曲线轨迹，其特征是逐渐减速。雄性的初始生长速度较慢，但加速速度更快。哮喘控制显著影响肺功能的改善。

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来源期刊

Journal of Pediatric Health Care NURSING-PEDIATRICS

CiteScore

3.40

自引率

10.70%

发文量

140

审稿时长

24 days

期刊介绍： The Journal of Pediatric Health Care, the official journal of the National Association of Pediatric Nurse Practitioners, provides scholarly clinical information and research regarding primary, acute and specialty health care for children of newborn age through young adulthood within a family-centered context. The Journal disseminates multidisciplinary perspectives on evidence-based practice and emerging policy, advocacy and educational issues that are of importance to all healthcare professionals caring for children and their families.