L1 cell adhesion molecule: A novel potential biomarker for IE patients at high risk of embolism and adverse events.

IF 2.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Hellenic Journal of Cardiology Pub Date : 2025-03-07 DOI:10.1016/j.hjc.2025.03.001

Jian Hou, Dayu Wang, Tingfeng Chen, Zhen Liu, Ruibing Wei, Cuiping Wang, Suiqing Huang

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引用次数: 0

Abstract

Aims: Despite advancements in medical and surgical therapies, infectious endocarditis (IE) remains life-threatening due to its complications. This study aimed to evaluate the clinical value and function of L1 cell adhesion molecule (L1CAM) in IE.

Methods: A prospective observational study included 94 IE patients (40 with embolic events [EEs], 54 without; 38 with adverse events, 56 without) and 25 healthy controls. Adverse events were defined as death or poorly controlled conditions requiring surgery. Plasma L1CAM levels were measured using enzyme-linked immunosorbent assays. Logistic regression and receiver operating characteristic (ROC) curves assessed L1CAM's predictive value for EEs and adverse events.

Results: L1CAM levels were higher in IE patients than in healthy controls (47.60 ± 10.86 vs. 94.80 ± 68.84 pg/mL, P = 0.008). Among IE patients, those with EEs or adverse events had significantly elevated L1CAM levels (EEs: 127.70 ± 78.20 vs. 70.45 ± 48.96 pg/mL; adverse events: 129.00 ± 79.79 vs. 71.59 ± 48.73 pg/mL, both P < 0.001). Multivariate analysis showed L1CAM as an independent predictor for EEs (OR = 1.02; 95% CI = 1.01-1.04; P = 0.001) and adverse events (OR = 1.01; 95% CI = 1.00-1.02; P = 0.003). AUCs were 0.7273 and 0.7119 for EEs and adverse events, respectively. L1CAM correlated positively with WBC (P = 0.028, r = 0.225) and CRP levels (P = 0.025, r = 0.231).

Conclusions: L1CAM may serve as a biomarker for embolism and adverse events in IE patients.

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来源期刊

Hellenic Journal of Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.90

自引率

7.30%

发文量

审稿时长

56 days

期刊介绍： The Hellenic Journal of Cardiology (International Edition, ISSN 1109-9666) is the official journal of the Hellenic Society of Cardiology and aims to publish high-quality articles on all aspects of cardiovascular medicine. A primary goal is to publish in each issue a number of original articles related to clinical and basic research. Many of these will be accompanied by invited editorial comments. Hot topics, such as molecular cardiology, and innovative cardiac imaging and electrophysiological mapping techniques, will appear frequently in the journal in the form of invited expert articles or special reports. The Editorial Committee also attaches great importance to subjects related to continuing medical education, the implementation of guidelines and cost effectiveness in cardiology.