Mohammed Abidullah, Bushra Anjum, Shaikh Mohammed Imran Saudagar, Swathi Jahagirdar, Peddisetty Govind Raj Pankaj Mallik, Mediconda Shivaratna
{"title":"Assessment of Expression of Mast Cells Density in Oral Premalignant and Malignant Lesions by Histochemical Analysis.","authors":"Mohammed Abidullah, Bushra Anjum, Shaikh Mohammed Imran Saudagar, Swathi Jahagirdar, Peddisetty Govind Raj Pankaj Mallik, Mediconda Shivaratna","doi":"10.4103/jpbs.jpbs_920_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>Assessment of mast cells density expression in oral premalignant and malignant lesions by histochemical analysis.</p><p><strong>Materials and methods: </strong>The study used a total of 120 tissue blocks that were formalin-fixed and paraffin-embedded. These blocks consisted of 40 cases of oral squamous cell carcinoma (OSCC), 40 cases of oral epithelial dysplasia, and 40 cases of normal oral mucosa (NOM).</p><p><strong>Results: </strong>In the current investigation, a comparison was made between toluidine blue stained sections of normal oral mucosa, oral epithelial dysplasia and OSCC. The resultant <i>P</i> value was determined to be statistically insignificant in all three categories, namely, oral epithelial dysplasia, oral squamous cell carcinoma (OSCC), and normal oral mucosa. The resultant <i>P</i> values, calculated using an unpaired <i>t</i>-test, were shown to be extremely significant (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Research indicates that mast cells could be a significant marker for increased angiogenesis, which in turn could be used to predict carcinogenesis, its progression, and the prognosis of malignant lesions.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 5","pages":"S4765-S4768"},"PeriodicalIF":0.9000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11888627/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacy & bioallied sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jpbs.jpbs_920_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/30 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: Assessment of mast cells density expression in oral premalignant and malignant lesions by histochemical analysis.
Materials and methods: The study used a total of 120 tissue blocks that were formalin-fixed and paraffin-embedded. These blocks consisted of 40 cases of oral squamous cell carcinoma (OSCC), 40 cases of oral epithelial dysplasia, and 40 cases of normal oral mucosa (NOM).
Results: In the current investigation, a comparison was made between toluidine blue stained sections of normal oral mucosa, oral epithelial dysplasia and OSCC. The resultant P value was determined to be statistically insignificant in all three categories, namely, oral epithelial dysplasia, oral squamous cell carcinoma (OSCC), and normal oral mucosa. The resultant P values, calculated using an unpaired t-test, were shown to be extremely significant (P = 0.001).
Conclusion: Research indicates that mast cells could be a significant marker for increased angiogenesis, which in turn could be used to predict carcinogenesis, its progression, and the prognosis of malignant lesions.
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