NK resident memory cells arise from NK cells that accumulate in tissues independently of persistent local infection

IF 25.5 1区 医学 Q1 IMMUNOLOGY Immunity Pub Date : 2025-03-11 DOI:10.1016/j.immuni.2025.02.019
Iona S. Schuster, Matthew E. Wikstrom, Christopher E. Andoniou, Mariapia A. Degli-Esposti
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Abstract

Section snippets

Main text

A recent study by Gasteiger and colleagues1 described a population of circulating natural killer (NK) cells that are recruited and retained in the skin for several weeks following local viral (vaccinia virus) and bacterial (Staphylococcus aureus) infections. These cells, which the authors refer to as tissue resident (tr)NK cells, exhibit increased production of effector molecules (interferon [IFN]-γ, granzyme B [Gzmb], perforin [Prf1]) upon re-challenge, suggesting a role in enhanced pathogen

Acknowledgments

The work was supported by funding from the National Health and Medical Research Council of Australia (NHMRC 2004397, 1119298, and 2026377).

Declaration of interests

The authors declare no competing interests.
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来源期刊
Immunity
Immunity 医学-免疫学
CiteScore
49.40
自引率
2.20%
发文量
205
审稿时长
6 months
期刊介绍: Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.
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