Ultrasonic-promoted synthesis of amino methylene bisphosphonates by sulfated choline ionic liquid

Abstract

A highly organized and green protocol has been developed for fabricating amino methylene bisphosphonates using sulfated choline ionic liquid (SCIL) catalyzed under ultrasonication. This method involves various substituted amines, triethyl orthoformate, and diethyl phosphite. All synthesized derivatives were characterized by Nuclear Magnetic Resonance NMR (¹H and ¹³C), confirming product formation. This approach significantly enhances the synthesis of desired products with high yields. The choline is biodegradable and it was widely used to prepare deep eutectic solvents and to synthesis of ionic liquid to replace the Cl⁻ ion to hydroxide ion it gives good basicity, and modification of terminal hydrogen is replaced by ClSO₃H it gives good acidity; hence the choline-based catalyst can use in both acid and base promoted reaction. The synthesized SCIL was characterized using by Fourier transform infrared (FT-IR), Thermogravimetric analysis (TGA), X-ray diffraction (XRD) and Scanning electron microscope (SEM) demonstrating the functionalization of the sulfonate group to form an effective acidic ionic liquid.Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 2 Given name: [Reddi Mohan Naidu] Last name [Kalla], Author 3 Given name: [Araveeti Eswar] Last name [Reddy] and Author 4 Given name: [Tahani Mazyad] Last name [Almutairi]. Also, kindly confirm the details in the metadata are correct.Yes the author detials were correct

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