Remarkable 99mTc-FAPI-46 Uptake in a Patient With Anaplastic Thyroid Carcinoma: A Promising Step in Theranostic Field.

IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical Nuclear Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI:10.1097/RLU.0000000000005746
Mitra Ghahraman, Pegah Sahafi, Mohammad Hadi Samadi, Kamran Aryana, Atena Aghaee
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Abstract

Fibroblast activation protein (FAP)-targeted radionuclides are known as a promising step in cancer diagnosis and treatment (theranostic), although it is still a subject under investigation. We present a patient with anaplastic thyroid carcinoma who underwent 99mTc-FAPI-46 SPECT/CT for the evaluation of metastatic disease. Several metastatic sites were found with considerable 99mTc-FAPI-46 uptake. Malignant FAPI uptake was observed in the large calcified thyroid mass, mediastinal lymph node, both lungs, liver, few skeletal sites, and around knees prostheses. Given the notable uptake of lesions, the patient was considered as a candidate for FAP-targeted radionuclide therapy.

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99mTc-FAPI-46在间变性甲状腺癌患者中的显著摄取:治疗领域的一个有希望的步骤。
众所周知,以成纤维细胞活化蛋白(FAP)为靶标的放射性核素是癌症诊断和治疗(治疗学)的一个很有前景的步骤,尽管它仍然是一个正在研究的课题。我们介绍了一名接受 99mTc-FAPI-46 SPECT/CT 检查以评估转移性疾病的甲状腺无节细胞癌患者。发现多个转移部位有大量的 99mTc-FAPI-46 摄取。在大的甲状腺钙化肿块、纵隔淋巴结、双肺、肝脏、少数骨骼部位和膝关节假体周围都观察到了恶性FAPI摄取。鉴于病变部位的明显摄取,该患者被视为 FAP 靶向放射性核素治疗的候选者。
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来源期刊
Clinical Nuclear Medicine
Clinical Nuclear Medicine 医学-核医学
CiteScore
2.90
自引率
31.10%
发文量
1113
审稿时长
2 months
期刊介绍: Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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