Ko Yamagata, Yousuke Mizuno, Yumi Mizuno, Shunnsuke Tamaru, Takeshi Kajihara
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引用次数: 0
Abstract
Human endometrium is the major target tissue for sex steroid hormones. The circulating steroid hormones in normal ovulatory cycles accurately control the proliferation and differentiation of the endometrial cells. Androgens, such as testosterone and 5α-dihydrotestosterone, are a type of sex steroid hormones that mainly function in the differentiation, development, and maintenance of male sexual characteristics. Although androgens are best known for their role in male reproduction, the androgen receptor is present in both male and female reproductive organs and is essential for normal reproductive function. Recently, a series of evidence suggests that androgens contribute to endometrial physiology and pathologies. However, the roles of androgens in the endometrium remain insufficiently understood, with contradictory findings being reported. This review summarizes the studies that show the role of androgens in regulating the physiological conditions of the endometrium and the implantation process, and endometrial pathology including endometriosis and others.
期刊介绍:
Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization.
Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.