The role of oxidative disorders in the pathogenesis of kidney damage in type 1 diabetes mellitus and diabetic nephropathy in children: xanthine oxidase as a trigger.

Q3 Medicine Polski Merkuriusz Lekarski Pub Date : 2025-01-01 DOI:10.36740/Merkur202501115

Ievgeniia A Burlaka, Ihor V Kovalchuk, Inga O Mityuryayeva-Kornijko

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Abstract

Objective: . Aim: This review aims to analyze scientific articles and publications on the role of oxidative stress and xanthine oxidase in the pathogenesis of type 1 diabetes mellitus and diabetic nephropathy in order to update the theories underlying its development and progression.

Patients and methods: Materials and Methods: The literature analysis used peer-reviewed articles, reviews, and descriptions of experimental studies from 2021-2024. The study describes the role of oxidative damage in the pathogenesis of diabetic nephropathy and the function of xanthine oxidase as a trigger.

Conclusion: Conclusions: The study of the molecular mechanisms of the cytoprotective and renoprotective effects of xanthine oxidase inhibition confirms its leading role in the pathogenesis of diabetic nephropathy and opens up new prospects for the development of biomarkers, and therefore new approaches in the diagnosis, treatment, and prevention of diabetes and its dangerous complications.

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氧化障碍在1型糖尿病和儿童糖尿病肾病肾损害发病机制中的作用：黄嘌呤氧化酶作为触发器

目的：.目的：本综述旨在分析有关氧化应激和黄嘌呤氧化酶在 1 型糖尿病和糖尿病肾病发病机制中的作用的科学文章和出版物，以更新其发病和进展的基础理论：材料与方法：文献分析采用了2021-2024年同行评议文章、综述和实验研究描述。研究描述了氧化损伤在糖尿病肾病发病机制中的作用以及黄嘌呤氧化酶作为诱因的功能.结论：结论：结论：对抑制黄嘌呤氧化酶的细胞保护和肾保护作用的分子机制的研究证实了其在糖尿病肾病发病机制中的主导作用，并为生物标志物的开发开辟了新的前景，从而为糖尿病及其危险并发症的诊断、治疗和预防提供了新的方法。

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Polski Merkuriusz Lekarski Medicine-Medicine (all)

CiteScore

1.90

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0.00%

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