S M Ragsdale, J M Radovich, I I Coiduras, W V McCall, S C Grant, C Lee, A Wilber
{"title":"Dual orexin receptor antagonists as promising therapeutics for Alzheimer's disease.","authors":"S M Ragsdale, J M Radovich, I I Coiduras, W V McCall, S C Grant, C Lee, A Wilber","doi":"10.1038/s44323-025-00025-5","DOIUrl":null,"url":null,"abstract":"<p><p>We examine the relationship between sleep, glymphatics and Alzheimer's disease (AD), and recent work questioning glymphatic clearance during sleep. We highlight a need for understanding glymphatic and/or other mechanism of clearance during sleep, and review glymphatic flow measurement methods. Further, we explore dual orexin receptor antagonists (DORAs) potential to mitigate AD sleep disturbances and enhance clearance. Further research could elucidate a linkage between DORAs, improved sleep and reducing AD pathophysiology.</p>","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":"11"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890173/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Biological Timing and Sleep","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s44323-025-00025-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/8 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We examine the relationship between sleep, glymphatics and Alzheimer's disease (AD), and recent work questioning glymphatic clearance during sleep. We highlight a need for understanding glymphatic and/or other mechanism of clearance during sleep, and review glymphatic flow measurement methods. Further, we explore dual orexin receptor antagonists (DORAs) potential to mitigate AD sleep disturbances and enhance clearance. Further research could elucidate a linkage between DORAs, improved sleep and reducing AD pathophysiology.
我们研究了睡眠、糖代谢和阿尔茨海默病（AD）之间的关系，以及最近有关睡眠时糖代谢清除的研究。我们强调有必要了解睡眠过程中的甘液和/或其他清除机制，并回顾了甘液流量测量方法。此外，我们还探讨了双奥曲肽受体拮抗剂（DORAs）在缓解 AD 睡眠障碍和提高清除率方面的潜力。进一步的研究可以阐明 DORAs、改善睡眠和减少注意力缺失症病理生理学之间的联系。
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