Compact Monocular Video-Ophthalmoscope to Measure Retinal Reflectance Changes to Flicker Light Stimuli.

Journal of biophotonics Pub Date : 2025-03-11 DOI:10.1002/jbio.202400494

Radim Kolar, Tomas Vicar, Jiri Chmelik, Roman Jakubicek, Jan Odstrcilik, Michal Nohel, Karolina Skorkovska, Ralf P Tornow

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Abstract

This paper describes a compact video-ophthalmoscope (VO) designed for capturing retinal video sequences of the optic nerve head (ONH) under flicker light stimulation. The device uses an OLED display and a fiber optic-coupled LED light source, enabling high-frame-rate video at low illumination intensity (12 μW/cm²). Retinal responses were recorded in 10 healthy subjects during flicker light exposure with a pupil irradiance of 2 μW/cm². Following 20 s of stimulation, all subjects displayed changes in retinal reflectance and pulsation attenuation, linked to blood flow and volume variations. These findings suggest that increased blood volume leads to decreased retinal reflectance. Temporal analysis confirmed the ability to capture flicker-induced retinal reflectance changes, indicating its potential for spatial and temporal analysis. Overall, this device offers a portable approach for investigating dynamic retinal responses to light stimuli, which can aid the diagnosis of retinal diseases like diabetic retinopathy, glaucoma, or neurodegenerative diseases affecting retinal blood circulation.

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本文介绍了一种紧凑型视频眼底镜（VO），设计用于捕捉闪烁光刺激下视神经头（ONH）的视网膜视频序列。该设备使用 OLED 显示屏和光纤耦合 LED 光源，可在低照明强度（12 μW/cm2）下实现高帧率视频。在瞳孔辐照度为 2 μW/cm2 的闪烁光照射下，记录了 10 名健康受试者的视网膜反应。刺激 20 秒后，所有受试者的视网膜反射率和脉动衰减都发生了变化，这与血流量和血容量的变化有关。这些发现表明，血容量增加会导致视网膜反射率下降。时间分析证实了捕捉闪烁诱导的视网膜反射率变化的能力，表明它具有进行空间和时间分析的潜力。总之，该设备为研究视网膜对光刺激的动态反应提供了一种便携式方法，有助于诊断糖尿病视网膜病变、青光眼或影响视网膜血液循环的神经退行性疾病等视网膜疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of biophotonics

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