{"title":"Glucose-insulin regulatory system: Chaos control and stability analysis via Atangana–Baleanu fractal-fractional derivatives","authors":"Muflih Alhazmi , Sayed Saber","doi":"10.1016/j.aej.2025.02.066","DOIUrl":null,"url":null,"abstract":"<div><div>This study explores the glucose-insulin regulatory system using a fractal-fractional framework based on the Atangana–Baleanu derivative. By formulating a set of differential equations incorporating the Atangana–Baleanu fractal-fractional derivative, we capture the intricate, nonlinear dynamics of glucose and insulin. This is with enhanced accuracy compared to traditional models. We establish the existence and uniqueness of solutions through fixed-point theory and analyze Hyers–Ulam stability. Moreover, we employ a linear controller to stabilize chaotic behavior in the system, mitigating fluctuations that can lead to erratic physiological responses. Both analytical and numerical results validate the model’s robustness to representing physiological processes. Our findings demonstrate that the fractal-fractional model significantly improves glucose-insulin dynamics modeling, highlighting its potential as a powerful tool for diabetes management and prediction of complex biological behaviors.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"122 ","pages":"Pages 77-90"},"PeriodicalIF":6.2000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"alexandria engineering journal","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1110016825002443","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
This study explores the glucose-insulin regulatory system using a fractal-fractional framework based on the Atangana–Baleanu derivative. By formulating a set of differential equations incorporating the Atangana–Baleanu fractal-fractional derivative, we capture the intricate, nonlinear dynamics of glucose and insulin. This is with enhanced accuracy compared to traditional models. We establish the existence and uniqueness of solutions through fixed-point theory and analyze Hyers–Ulam stability. Moreover, we employ a linear controller to stabilize chaotic behavior in the system, mitigating fluctuations that can lead to erratic physiological responses. Both analytical and numerical results validate the model’s robustness to representing physiological processes. Our findings demonstrate that the fractal-fractional model significantly improves glucose-insulin dynamics modeling, highlighting its potential as a powerful tool for diabetes management and prediction of complex biological behaviors.
期刊介绍:
Alexandria Engineering Journal is an international journal devoted to publishing high quality papers in the field of engineering and applied science. Alexandria Engineering Journal is cited in the Engineering Information Services (EIS) and the Chemical Abstracts (CA). The papers published in Alexandria Engineering Journal are grouped into five sections, according to the following classification:
• Mechanical, Production, Marine and Textile Engineering
• Electrical Engineering, Computer Science and Nuclear Engineering
• Civil and Architecture Engineering
• Chemical Engineering and Applied Sciences
• Environmental Engineering