Near-infrared fluorescent BODIPY dyes: Green synthesis, photophysical properties, and their applications in biomedical molecular imaging

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2025-08-01 Epub Date: 2025-03-07 DOI:10.1016/j.dyepig.2025.112740

Raúl Segovia-Pérez, Marisol Ibarra-Rodríguez, Blanca M. Muñoz-Flores, Víctor M. Jiménez-Pérez

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Abstract

This review examines available data on BODIPYs with near-infrared (NIR) fluorescent properties. BODIPYs, widely used as fluorescent dyes, offer facile modification and the potential for high quantum yields, making them valuable for various applications. The first section focuses on sustainable synthesis methods, including mechanosynthesis, microwave-assisted synthesis, and multicomponent reactions, as well as the photophysical properties of BODIPYs. The second section explores their biomedical applications in molecular imaging, where they serve as markers, sensors, and therapeutic agents. Their NIR fluorescence enables deeper tissue penetration and reduced autofluorescence, enhancing imaging accuracy. This review provides a comprehensive and critical perspective on green synthesis strategies, NIR optical properties, and biomedical applications of BODIPY. Additionally, it highlights key challenges and future prospects, particularly in medical diagnostics and treatment.

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近红外荧光BODIPY染料：绿色合成、光物理性质及其在生物医学分子成像中的应用

本文综述了具有近红外（NIR）荧光特性的BODIPYs的现有数据。BODIPYs被广泛用作荧光染料，具有易于修饰和高量子产率的潜力，因此具有广泛的应用价值。第一部分重点介绍了可持续合成方法，包括机械合成、微波辅助合成和多组分反应，以及BODIPYs的光物理性质。第二部分探讨了它们在分子成像中的生物医学应用，它们可以作为标记物、传感器和治疗剂。它们的近红外荧光能够更深地穿透组织，减少自身荧光，提高成像精度。本文综述了BODIPY的绿色合成策略、近红外光学特性和生物医学应用等方面的研究进展。此外，报告还强调了主要挑战和未来前景，特别是在医疗诊断和治疗方面。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.