Mineralized cellulose nanofibers reinforced bioactive hydrogel remodels the osteogenic and angiogenic microenvironment for enhancing bone regeneration

IF 10.7 1区 化学 Q1 CHEMISTRY, APPLIED Carbohydrate Polymers Pub Date : 2025-03-08 DOI:10.1016/j.carbpol.2025.123480
Xiaokang Liu , Haoran Hu , Jinghong Ma , Baoxiu Wang
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引用次数: 0

Abstract

Slow osteogenesis and insufficient vascularization remain significant challenges in achieving effective bone repair and functional restoration with tissue-engineered scaffolds. Herein, a novel mineralized nanofibers reinforced bioactive hydrogel was designed to enhance bone regeneration inspired from the structural and functional properties of the bone tissue extracellular matrix (ECM). This bioactive hydrogel integrated enzymatically mineralized TEMPO-oxidized bacterial cellulose (m-TOBC) nanofibers and mesoporous silica nanoparticles (MSNs) loaded with the angiogenic drug dimethyloxalylglycine (DMOG) into gelatin methacryloyl (GelMA). The m-TOBC nanofibers achieved one stone, three birds: improving the printability of GelMA ink, mechanical properties, and osteoconduction of the hydrogel. The incorporation of MSNs loaded with DMOG fostered an angiogenic microenvironment through the release of DMOG. Results indicated that the bioactive hydrogel significantly enhanced in vitro mineralized matrix deposition and osteoblastic alkaline phosphatase expression. Additionally, the bioactive hydrogel had good ability to promote angiogenesis in terms of enhanced endothelial cell migration, tube formation, and upregulated angiogenic genes expression levels. In a critical-sized rat cranial defect model, the bioactive hydrogel significantly enhanced bone regeneration. Overall, this research offered a promising strategy to design nanofibers enhanced hydrogel to remodel osteogenic and angiogenic microenvironment for enhancing bone repair.
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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
期刊最新文献
Expression of concern: "Synthesis and evaluation of chondroitin sulfate based hydrogels of loxoprofen with adjustable properties as controlled release carriers" [Carbohydrate Polymers volume 181, 1 February 2018, pages 1169-1179]. Composites of bacterial cellulose and alginate produced in situ: The impact of viscosity and temperature on the microscale morphology Preparation of temperature-dependent flux controllable cellulose nanofiber-based films and their application in oil-water separation Synthesis and biological evaluation of mirror isomers of β-(1 → 3)-glucans as immune modulators Mineralized cellulose nanofibers reinforced bioactive hydrogel remodels the osteogenic and angiogenic microenvironment for enhancing bone regeneration
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