Fusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori.

IF 1.7 Q2 MULTIDISCIPLINARY SCIENCES BMC Research Notes Pub Date : 2025-03-11 DOI:10.1186/s13104-025-07165-8

Negin Kamali, Amin Talebi Bezmin Abadi, Farid Rahimi, Mojgan Forootan

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Abstract

Objective: Putative associations between certain bacteria and gastric cancer have been described previously; however, the mechanisms underlying such associations are not thoroughly understood. We aimed to confirm the presence of Fusobacterium nucleatum in the biopsy samples of patients with gastroduodenal diseases, including gastric cancer, with concomitant or without Helicobacter pylori infection.

Results: Three hundred patients with gastroduodenal disorders, including gastritis, duodenal ulcer, or gastric cancer, were included. One hundred and eighty (60%) patients were negative and 120 (40%) positive for H. pylori. Associations between the presence of H. pylori and age, gender, or other demographics were statistically insignificant (p > 0.05). The prevalence of F. nucleatum infection was determined for the two patient categories: 215 patients (72%) were positive for F. nucleatum; of these cases, 95 showed evidence of, and 120 lacked, concomitant H. pylori infection. Gastric biopsies obtained from patients with gastric cancer but negative for H. pylori revealed a significant prevalence of F. nucleatum infection.

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无幽门螺杆菌患者胃活检证实有核梭杆菌。

目的：某些细菌与胃癌之间的推定关联先前已被描述；然而，这种关联背后的机制并没有被完全理解。我们的目的是确认胃十二指肠疾病（包括胃癌）合并或不合并幽门螺杆菌感染的活检样本中存在核梭杆菌。结果：纳入胃十二指肠疾病患者300例，包括胃炎、十二指肠溃疡或胃癌。180例（60%）幽门螺杆菌阴性，120例（40%）幽门螺杆菌阳性。幽门螺杆菌的存在与年龄、性别或其他人口统计数据之间的相关性无统计学意义（p < 0.05）。测定两类患者的具核梭菌感染流行率：215例（72%）具核梭菌阳性；在这些病例中，95例显示有幽门螺杆菌感染的证据，120例没有。胃癌患者胃活检，但幽门螺旋杆菌阴性显示具核胞杆菌感染的显著流行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Research Notes Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

3.60

自引率

0.00%

发文量

363

审稿时长

15 weeks

期刊介绍： BMC Research Notes publishes scientifically valid research outputs that cannot be considered as full research or methodology articles. We support the research community across all scientific and clinical disciplines by providing an open access forum for sharing data and useful information; this includes, but is not limited to, updates to previous work, additions to established methods, short publications, null results, research proposals and data management plans.