Case Report and Literature Review of 10 Pediatric Cases of Knee Pigmented Villonodular Synovitis.

IF 1 4区 医学 Q3 PEDIATRICS Clinical Pediatrics Pub Date : 2025-03-12 DOI:10.1177/00099228251316428
Yanan Ma, Kun Zhang, Sainan Fan, Shun Liu, Jinping Zhang
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Abstract

Objective: This study was aimed to analyze 10 pediatric cases of pigmented villonodular synovitis (PVNS) of the knee to elucidate their clinical features, diagnosis, treatments, and prognosis for providing reference regarding its clinical management in children.

Methods: A retrospective analysis was made pertaining to the clinical manifestations, magnetic resonance imaging (MRI) findings, pathology, immunohistochemical results, treatment methods, and follow-up outcomes of 10 pediatric PVNS patients of the knee treated from January 2022 to January 2024 at our hospital. They were compared and analyzed with existing literature.

Results: (1) All 10 patients had joint swelling with restricted movement, mainly in older female children with male-to-female ratio of 3:7 and average age of 14.1 ± 3.6 years; (2) diagnostic positive rate of MRI was 80%; (3) significant features of PVNS were the appearance of villous and nodular hyperplasia on synovial surface and deposition of brownish-yellow granular hemosiderin. Immunohistochemical staining results were clusterin (synovial cells+), D2-40 (synovial cells+), CD163 (histiocytes+), KP-1 (histiocytes+), CD31 (vascular+), P63 (-), and Ki67 (+, 1%-10%); and (4) all patients underwent arthroscopic surgery with 20% recurrence rate.

Conclusion: Pediatric knee PVNS is more prevalent in older female children. The PVNS diagnosis is carried out by MRI, pathology, and immunohistochemistry. Arthroscopic surgery is effective for treating this condition in children.

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研究目的本研究旨在分析10例小儿膝关节色素性绒毛膜滑膜炎(PVNS)病例,以阐明其临床特征、诊断、治疗和预后,为儿童临床治疗提供参考:方法:对本院自2022年1月至2024年1月收治的10例小儿膝关节PVNS患者的临床表现、磁共振成像(MRI)结果、病理、免疫组化结果、治疗方法和随访结果进行回顾性分析。结果:(1)10 例患者均出现关节肿胀,活动受限,以年龄较大的女性儿童为主,男女比例为 3:7,平均年龄为(14.1±3.6)岁;(2)MRI 诊断阳性率为 80%;(3)PVNS 的显著特征是滑膜表面出现绒毛状和结节状增生,棕黄色颗粒状血色素沉积。免疫组化染色结果为群集素(滑膜细胞+)、D2-40(滑膜细胞+)、CD163(组织细胞+)、KP-1(组织细胞+)、CD31(血管+)、P63(-)和Ki67(+,1%-10%);(4)所有患者均接受了关节镜手术,复发率为20%:结论:小儿膝关节PVNS多发于年龄较大的女性儿童。结论:小儿膝关节 PVNS 多发于年龄较大的女性儿童。关节镜手术能有效治疗儿童的这种疾病。
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来源期刊
Clinical Pediatrics
Clinical Pediatrics 医学-小儿科
CiteScore
2.10
自引率
6.20%
发文量
189
审稿时长
3-8 weeks
期刊介绍: Clinical Pediatrics (CLP) a peer-reviewed monthly journal, is a must read for the busy pediatrician. CLP contains state-of-the-art, accurate, concise and down-to earth information on practical, everyday child care topics whether they are clinical, scientific, behavioral, educational, or ethical.
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